D
David J. Sharp
Researcher at Imperial College London
Publications - 233
Citations - 16427
David J. Sharp is an academic researcher from Imperial College London. The author has contributed to research in topics: Traumatic brain injury & Medicine. The author has an hindex of 56, co-authored 198 publications receiving 12805 citations. Previous affiliations of David J. Sharp include National Institutes of Health & Royal Free Hospital.
Papers
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Journal ArticleDOI
The role of the posterior cingulate cortex in cognition and disease.
Robert Leech,David J. Sharp +1 more
TL;DR: A novel model of the posterior cingulate cortex's function is synthesized into a model that influences attentional focus by 'tuning' whole-brain metastability and so adjusts how stable brain network activity is over time, and is tested within the framework of complex dynamic systems theory.
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Inflammation after trauma: Microglial activation and traumatic brain injury
Anil F. Ramlackhansingh,David J. Brooks,Richard Greenwood,Subrata K. Bose,Federico Turkheimer,Kirsi M. Kinnunen,Steve M. Gentleman,Rolf A. Heckemann,Karen Gunanayagam,Giorgio Gelosa,David J. Sharp +10 more
TL;DR: This study investigates whether an inflammatory response to TBI persists, and whether this response relates to structural brain abnormalities and cognitive function.
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Fractionating the Default Mode Network: Distinct Contributions of the Ventral and Dorsal Posterior Cingulate Cortex to Cognitive Control
TL;DR: Results provide evidence that the posterior cingulate cortex is involved in supporting internally directed thought, as the region is more highly integrated with the DMN at low task demands.
Journal ArticleDOI
White matter damage and cognitive impairment after traumatic brain injury.
Kirsi M. Kinnunen,Richard Greenwood,Jane H. Powell,Robert Leech,Peter C.T. Hawkins,Valerie Bonnelle,Maneesh C. Patel,Serena J. Counsell,David J. Sharp +8 more
TL;DR: A stratified analysis based on the presence or absence of microbleeds revealed diffusion tensor imaging to be more sensitive than gradient-echo imaging to white matter damage and the location of white matter abnormality predicted cognitive function to some extent.
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Echoes of the Brain within the Posterior Cingulate Cortex
TL;DR: PCC subregions showed distinct patterns of activity modulation during the performance of an attentionally demanding task, suggesting that parts of the dorsal PCC interact with frontoparietal networks to regulate the balance between internally and externally directed cognition.