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David L. Pincus
Researcher at Columbia University
Publications - 5
Citations - 2680
David L. Pincus is an academic researcher from Columbia University. The author has contributed to research in topics: Gene & Algebraic number field. The author has an hindex of 4, co-authored 4 publications receiving 2216 citations.
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Journal ArticleDOI
A hierarchical approach to all-atom protein loop prediction.
Matthew P. Jacobson,David L. Pincus,Chaya S. Rapp,Tyler Day,Barry Honig,David E. Shaw,Richard A. Friesner +6 more
TL;DR: The overall results are the best reported to date, and the combination of an accurate all‐atom energy function, efficient methods for loop buildup and side‐chain optimization, and, especially for the longer loops, the hierarchical refinement protocol is attributed.
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Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21
Vincent M. Aita,Xiao Huan Liang,Vundavalli V. Murty,David L. Pincus,Weiping Yu,Eftihia Cayanis,Sergei Kalachikov,T. Conrad Gilliam,Beth Levine +8 more
TL;DR: The results indicate that human breast carcinoma cell lines frequently contain allelic deletions of beClin 1, but not beclin 1 coding mutations.
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Long loop prediction using the protein local optimization program.
TL;DR: An improved sampling algorithm and energy model for protein loop prediction has yielded the first methodology capable of achieving good results for the prediction of loop backbone conformations of 11 residue length or greater, and the inclusion of a hydrophobic term appears to approximately fix a major flaw in SGB solvation model.
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Protein structure prediction using a combination of sequence‐based alignment, constrained energy minimization, and structural alignment
Daron M. Standley,Volker A. Eyrich,Yuling An,David L. Pincus,John R. Gunn,Richard A. Friesner +5 more
TL;DR: A novel approach to protein structure prediction in which fold recognition techniques are combined with ab initio folding methods, based on the predicted secondary structure, which results in two different protocols being followed.
Journal ArticleDOI
Relative ideal classes of arbitrary order
TL;DR: In this paper , the authors adapted a technique for searching for ideal classes of arbitrary order and applied it to three families of number fields, namely cyclic sextic, quartic, and non-Galois cubic number fields.