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Xiao Huan Liang
Researcher at Columbia University
Publications - 15
Citations - 9961
Xiao Huan Liang is an academic researcher from Columbia University. The author has contributed to research in topics: Sindbis virus & Autophagy. The author has an hindex of 11, co-authored 12 publications receiving 9331 citations. Previous affiliations of Xiao Huan Liang include University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
Sophie Pattingre,Sophie Pattingre,Amina T. Tassa,Xueping Qu,Xueping Qu,Rita Garuti,Xiao Huan Liang,Noboru Mizushima,Milton Packer,Michael D. Schneider,Beth Levine,Beth Levine +11 more
TL;DR: Bcl-2 not only functions as an antiapoptotic protein, but also as an antiautophagy protein via its inhibitory interaction with Beclin 1, which may help maintain autophagy at levels that are compatible with cell survival, rather than cell death.
Journal ArticleDOI
Induction of autophagy and inhibition of tumorigenesis by beclin 1.
Xiao Huan Liang,Saadiya Jackson,Matthew N.J. Seaman,Kristy A. Brown,Bettina Kempkes,Hanina Hibshoosh,Beth Levine +6 more
TL;DR: It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.
Journal ArticleDOI
Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein
Xiao Huan Liang,Linda Kleeman,Hui Hui Jiang,Gerald W. Gordon,James E. Goldman,Gail Berry,Brian Herman,Brian Herman,Beth Levine +8 more
TL;DR: It is demonstrated that Beclin is a novel Bcl-2-interacting cellular protein that may play a role in antiviral host defense.
Journal ArticleDOI
Quantitative fluorescence resonance energy transfer measurements using fluorescence microscopy.
TL;DR: Measurements of the interaction of the proteins Bcl-2 and Beclin, are shown to document the accuracy of this approach for correction of donor and acceptor concentrations, and cross talk between the different filter units.
Journal ArticleDOI
Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21
Vincent M. Aita,Xiao Huan Liang,Vundavalli V. Murty,David L. Pincus,Weiping Yu,Eftihia Cayanis,Sergei Kalachikov,T. Conrad Gilliam,Beth Levine +8 more
TL;DR: The results indicate that human breast carcinoma cell lines frequently contain allelic deletions of beClin 1, but not beclin 1 coding mutations.