D
David M. Chenoweth
Researcher at University of Pennsylvania
Publications - 87
Citations - 2530
David M. Chenoweth is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: DNA & Chemistry. The author has an hindex of 26, co-authored 80 publications receiving 2034 citations. Previous affiliations of David M. Chenoweth include California Institute of Technology & Massachusetts Institute of Technology.
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Journal ArticleDOI
Spindle asymmetry drives non-Mendelian chromosome segregation
Takashi Akera,Lukáš Chmátal,Emily Trimm,Karren Yang,Chanat Aonbangkhen,David M. Chenoweth,Carsten Janke,Carsten Janke,Richard M. Schultz,Michael A. Lampson +9 more
TL;DR: It is found that CDC42 signaling from the cell cortex regulated microtubule tyrosination to induce spindle asymmetry and that non-Mendelian segregation depended on this asymmetry.
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Allosteric modulation of DNA by small molecules
TL;DR: This allosteric perturbation of the DNA helix provides a molecular basis for disruption of transcription factor-DNA interfaces by small molecules, a minimum step in chemical control of gene networks.
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Localized light-induced protein dimerization in living cells using a photocaged dimerizer
TL;DR: A new technique to rapidly and reversibly control protein localization in living cells with subcellular spatial resolution using a cell-permeable, photoactivatable chemical inducer of dimerization is presented.
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Rational design of small molecule fluorescent probes for biological applications
TL;DR: This review explores general factors affecting fluorophore excitation and emission spectra, molar absorption, Stokes shift, and quantum efficiency; provides guidelines for chemist to create novel probes and presents a survey of functional probes based on PeT, FRET, and environmental or photo-sensitivity.
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Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.
TL;DR: A high-resolution X-ray crystal structure of a β-amino turn-linked eight-ring cyclic Py-Im polyamide bound to the central six base pairs of the sequence d(5′-CCAGTACTGG-3′)2, revealing significant modulation of DNA shape is described, providing a molecular basis for disruption of transcription factor−DNA interfaces by small molecules.