D
David M. Rothstein
Researcher at University of Pittsburgh
Publications - 81
Citations - 3761
David M. Rothstein is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 35, co-authored 81 publications receiving 3323 citations. Previous affiliations of David M. Rothstein include Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
Qing Ding,Melissa Y. Yeung,Geoffrey Camirand,Qiang Zeng,Hisaya Akiba,Hideo Yagita,Geetha Chalasani,Mohamed H. Sayegh,Nader Najafian,David M. Rothstein +9 more
TL;DR: The findings suggest that TIM-1 may be a novel therapeutic target for modulating the immune response and provide insight into the signals involved in the generation and induction of Bregs.
Journal ArticleDOI
Non-self recognition by monocytes initiates allograft rejection
Martin H. Oberbarnscheidt,Qiang Zeng,Qi Li,Hehua Dai,Amanda L. Williams,Warren D. Shlomchik,David M. Rothstein,Fadi G. Lakkis +7 more
TL;DR: It is demonstrated that danger signals associated with dying cells are not sufficient to initiate alloimmunity, but that recognition of allogeneic non-self by the innate immune system is required.
Journal ArticleDOI
Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5.
David M. Rothstein,Peter Spacciapoli,Linh T. Tran,Tao Xu,F. Donald Roberts,Mauro Dalla Serra,Deborah K. Buxton,Frank G. Oppenheim,Phillip M. Friden +8 more
TL;DR: P-113, a 12-amino-acid fragment of histatin 5, is identified as a potential antimicrobial agent in the treatment of oral candidiasis and has potent activity against Candida albicans, Candida glabrata,candida parapsilosis, and Candida tropicalis.
Journal ArticleDOI
Antimicrobial activity of silver nitrate against periodontal pathogens
TL;DR: Results identify silver nitrate, an antimicrobial that may possess advantages over traditional antibiotics, as a potential agent for controlled release local delivery in the oral cavity for the treatment of periodontitis.
Journal ArticleDOI
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic
Trudy H. Grossman,Agata L. Starosta,Corey Fyfe,William J. O’Brien,David M. Rothstein,Aleksandra Mikolajka,Daniel N. Wilson,Daniel N. Wilson,Joyce A. Sutcliffe +8 more
TL;DR: The findings support the idea that TP-434, like other tetracyclines, binds the ribosome and inhibits protein synthesis and that this activity is largely unaffected by the common tetrACYcline resistance mechanisms.