M
Mohamed H. Sayegh
Researcher at Brigham and Women's Hospital
Publications - 488
Citations - 40228
Mohamed H. Sayegh is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Transplantation & T cell. The author has an hindex of 103, co-authored 485 publications receiving 38540 citations. Previous affiliations of Mohamed H. Sayegh include Keele University & Alfaisal University.
Papers
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Journal ArticleDOI
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Elisabeth M. Zeisberg,Oleg Tarnavski,Michael Zeisberg,Adam L. Dorfman,Julie R. McMullen,Erika Gustafsson,Anil Chandraker,Xueli Yuan,William T. Pu,Anita B. Roberts,Eric G. Neilson,Mohamed H. Sayegh,Seigo Izumo,Raghu Kalluri +13 more
TL;DR: It is shown that cardiac fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT) similar to events that occur during formation of the atrioventricular cushion in the embryonic heart.
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Identification of cells initiating human melanomas
Tobias Schatton,George F. Murphy,Natasha Y. Frank,Kazuhiro Yamaura,Ana Maria Waaga-Gasser,Martin Gasser,Qian Zhan,Stefan Jordan,Lyn M. Duncan,Carsten Weishaupt,Robert C. Fuhlbrigge,Thomas S. Kupper,Mohamed H. Sayegh,Markus H. Frank +13 more
TL;DR: This work identifies a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the chemoresistance mediator ABCB5 and shows that specific targeting of this tumorigenic minority population inhibits tumour growth.
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Tissue expression of PD-L1 mediates peripheral T cell tolerance
Mary E. Keir,Spencer Liang,Indira Guleria,Yvette Latchman,A. Qipo,Lee A. Albacker,Maria Koulmanda,Gordon J. Freeman,Mohamed H. Sayegh,Arlene H. Sharpe +9 more
TL;DR: Evidence is provided that PD-L 1 expression on parenchymal cells rather than hematopoietic cells protects against autoimmune diabetes and point to a novel role for PD-1–PD-L1 interactions in mediating tissue tolerance.
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Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens
Howard L. Weiner,Aharon Friedman,A. Miller,Samia J. Khoury,Ahmad Al-Sabbagh,Leonilda M.B. Santos,Mohamed H. Sayegh,R. B. Nussenblatt,David E. Trentham,David A. Hafler +9 more
TL;DR: Orally administered autoantigens suppress several experimental autoimmune models in a disease- and antigen-specific fashion; the diseases include experimental autoimmune encephalomyelitis, uveitis, and myasthenia, collagen- and adjuvant-induced arthritis, and diabetes in the NOD mouse.
Journal ArticleDOI
Delayed graft function in kidney transplantation.
TL;DR: It is learnt that both ischaemia and reinstitution of blood flow in ischaemically damaged kidneys after hypothermic preservation activate a complex sequence of events that sustain renal injury and play a pivotal part in the development of delayed graft function.