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Warren D. Shlomchik
Researcher at University of Pittsburgh
Publications - 94
Citations - 11082
Warren D. Shlomchik is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Graft-versus-host disease & Transplantation. The author has an hindex of 39, co-authored 82 publications receiving 10196 citations. Previous affiliations of Warren D. Shlomchik include University of Iowa & Yale Cancer Center.
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Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI
Graft-versus-host disease.
TL;DR: The full therapeutic potential of allogeneic haematopoietic SCT will not be realized until approaches to minimize GVHD, while maintaining the positive contributions of donor T cells are developed.
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Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
Warren D. Shlomchik,Matthew S. Couzens,Cheng Bi Tang,Jennifer M. McNiff,Marie E. Robert,Jinli Liu,Mark J. Shlomchik,Stephen G. Emerson +7 more
TL;DR: In this article, it was found that despite the presence of numerous donor antigen-presenting cells, only host-derived antigen presenting cells initiated graft versus host disease, and thus, strategies for preventing graft-versus-host disease could be developed that are based on inactivating host antigen-posing cells.
Journal ArticleDOI
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
TL;DR: It is found that contact hypersensitivity (CHS) was amplified rather than abrogated in the absence of LCs, and LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function.
Journal ArticleDOI
Memory CD4 + T cells do not induce graft-versus-host disease
Britt E. Anderson,Jennifer M. McNiff,Jun Yan,Hester A. Doyle,Mark J. Mamula,Mark J. Shlomchik,Warren D. Shlomchik +6 more
TL;DR: It was found that memory CD4 cells induced neither clinical nor histologic GVHD, and selective administration of memory T cells could greatly improve post-transplant immune reconstitution.