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David M. Sayah
Researcher at University of California, Los Angeles
Publications - 57
Citations - 2760
David M. Sayah is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Lung transplantation & Medicine. The author has an hindex of 20, co-authored 44 publications receiving 2291 citations. Previous affiliations of David M. Sayah include University of California, San Francisco & Columbia University.
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Journal ArticleDOI
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Beñat Mallavia,Fengchun Liu,David M. Sayah,Emily E. Thornton,Mark B. Headley,Tovo David,Shaun R. Coughlin,Matthew F. Krummel,Andrew D. Leavitt,Emmanuelle Passegué,Mark R. Looney +13 more
TL;DR: The lungs are identified as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.
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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1
TL;DR: It is shown that knockdown of owl monkey CypA by RNA interference (RNAi) correlates with suppression of anti-HIV-1 activity, and that TRIMCyp arose after the divergence of New and Old World primates, the first vertebrate example of a chimaeric gene generated by this mechanism of exon shuffling.
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Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity
TL;DR: It is clearly demonstrated that target cell CypA, and not producer cell CyA, is important for HIV-1 CA-mediated function, and inhibition of HIV- 1 infectivity resulting from virion production in the presence of CsA occurs independently of the CA-CypA interaction.
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Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction after Lung Transplantation
David M. Sayah,Beñat Mallavia,Fengchun Liu,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Ariss Derhovanessian,David J. Ross,Joseph P. Lynch,Rajan Saggar,Abbas Ardehali,Lorraine B. Ware,Jason D. Christie,John A. Belperio,Mark R. Looney +13 more
TL;DR: These data are the first description of a pathogenic role for NETs in solid organ transplantation and suggest that NETs are a promising therapeutic target in PGD.
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Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
TL;DR: The results suggest that NT4 plays a physiological role essential for hippocampus- and amygdala-dependent long-term memory and hippocampal long-lasting LTP and thatNT4 may be useful in the therapy of acquired disorders of learning and memory.