M
Mark R. Looney
Researcher at University of California, San Francisco
Publications - 124
Citations - 9664
Mark R. Looney is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Transfusion-related acute lung injury. The author has an hindex of 37, co-authored 106 publications receiving 7161 citations. Previous affiliations of Mark R. Looney include University of Tennessee Health Science Center & University of California.
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Journal ArticleDOI
Targeting potential drivers of COVID-19: Neutrophil extracellular traps.
Betsy J. Barnes,José M. Adrover,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Jonathan Cools-Lartigue,James M. Crawford,Juliane Daßler-Plenker,Philippe Guerci,Caroline Huynh,Jason S. Knight,Massimo Loda,Mark R. Looney,Florencia McAllister,Roni F. Rayes,Stéphane Renaud,Simon Rousseau,Steven P. Salvatore,Robert E. Schwartz,Jonathan Spicer,Christian C. Yost,Andrew G. Weber,Yu Zuo,Mikala Egeblad +22 more
TL;DR: Autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19, and existing drugs that target NETs, although unspecific, may benefit CO VID-19 patients.
Journal ArticleDOI
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
Axelle Caudrillier,Kai Kessenbrock,Brian M. Gilliss,John X. Nguyen,Marisa B. Marques,Marc Monestier,Pearl Toy,Zena Werb,Mark R. Looney +8 more
TL;DR: It is reported that activated platelets induce the formation of neutrophil extracellular traps (NETs) in transfusion-related acute lung injury (TRALI), which is the leading cause of death after transfusion therapy.
Journal ArticleDOI
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Beñat Mallavia,Fengchun Liu,David M. Sayah,Emily E. Thornton,Mark B. Headley,Tovo David,Shaun R. Coughlin,Matthew F. Krummel,Andrew D. Leavitt,Emmanuelle Passegué,Mark R. Looney +13 more
TL;DR: The lungs are identified as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.
Journal ArticleDOI
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury
Andrew E. Vaughan,Alexis N. Brumwell,Ying Xi,Jeffrey E. Gotts,Douglas Brownfield,Barbara Treutlein,Kevin Tan,Victor M. Tan,Fengchun Liu,Mark R. Looney,Michael A. Matthay,Jason R. Rock,Harold A. Chapman +12 more
TL;DR: It is indicated that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the injury, and the outcomes of regeneration or fibrosis may depend in part on the dynamics of LNEP Notch signalling.
Journal ArticleDOI
Transfusion-related acute lung injury: Incidence and risk factors
Pearl Toy,Ognjen Gajic,Peter Bacchetti,Mark R. Looney,Michael A. Gropper,Rolf D. Hubmayr,Clifford A. Lowell,Philip J. Norris,Philip J. Norris,Edward L. Murphy,Edward L. Murphy,Richard B. Weiskopf,Gregory A. Wilson,Monique Koenigsberg,Deanna C. Lee,Randy M. Schuller,Ping Wu,Barbara Grimes,Manish J. Gandhi,Jeffrey L. Winters,David C. Mair,Nora V. Hirschler,Nora V. Hirschler,Rosa Sanchez Rosen,Rosa Sanchez Rosen,Michael A. Matthay +25 more
TL;DR: The identified risk factors provide potential targets for reducing residual TRALI and little or no risk was associated with older red blood cell units, noncognate or weak cognate class II antibody, or class I antibody.