F
Fengchun Liu
Researcher at University of California, San Francisco
Publications - 17
Citations - 1984
Fengchun Liu is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Transplantation & Lung injury. The author has an hindex of 12, co-authored 16 publications receiving 1509 citations.
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Journal ArticleDOI
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Beñat Mallavia,Fengchun Liu,David M. Sayah,Emily E. Thornton,Mark B. Headley,Tovo David,Shaun R. Coughlin,Matthew F. Krummel,Andrew D. Leavitt,Emmanuelle Passegué,Mark R. Looney +13 more
TL;DR: The lungs are identified as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.
Journal ArticleDOI
Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury
Andrew E. Vaughan,Alexis N. Brumwell,Ying Xi,Jeffrey E. Gotts,Douglas Brownfield,Barbara Treutlein,Kevin Tan,Victor M. Tan,Fengchun Liu,Mark R. Looney,Michael A. Matthay,Jason R. Rock,Harold A. Chapman +12 more
TL;DR: It is indicated that distinct stem/progenitor cell pools repopulate injured tissue depending on the extent of the injury, and the outcomes of regeneration or fibrosis may depend in part on the dynamics of LNEP Notch signalling.
Journal ArticleDOI
Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction after Lung Transplantation
David M. Sayah,Beñat Mallavia,Fengchun Liu,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Ariss Derhovanessian,David J. Ross,Joseph P. Lynch,Rajan Saggar,Abbas Ardehali,Lorraine B. Ware,Jason D. Christie,John A. Belperio,Mark R. Looney +13 more
TL;DR: These data are the first description of a pathogenic role for NETs in solid organ transplantation and suggest that NETs are a promising therapeutic target in PGD.
Journal ArticleDOI
The Activating Immunoreceptor NKG2D and Its Ligands Are Involved in Allograft Transplant Rejection
Jim Kim,Catherine K. Chang,Tracy Hayden,Fengchun Liu,Jonathan Benjamin,Jessica A. Hamerman,Lewis L. Lanier,Lewis L. Lanier,Sang-Mo Kang +8 more
TL;DR: A functional role of NKG2D and its ligands in the rejection of solid organ transplants is established and early “danger” signals associated with transplantation lead to rapid up-regulation of NKg2D ligands.
Journal ArticleDOI
STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.
Hong Zhang,Regina A. Clemens,Fengchun Liu,Yongmei Hu,Yoshihiro Baba,Pierre Theodore,Tomohiro Kurosaki,Clifford A. Lowell +7 more
TL;DR: It is reported that STIM1-deficient murine neutrophils show loss of store-operated calcium entry (SOCE) in response to both soluble ligands that activate G-proteins as well as Fcγ-receptor or integrin ligation that activates tyrosine kinase signaling.