E
Emma Lefrançais
Researcher at University of Toulouse
Publications - 27
Citations - 2931
Emma Lefrançais is an academic researcher from University of Toulouse. The author has contributed to research in topics: Innate lymphoid cell & Immune system. The author has an hindex of 13, co-authored 23 publications receiving 2173 citations. Previous affiliations of Emma Lefrançais include Centre national de la recherche scientifique & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Beñat Mallavia,Fengchun Liu,David M. Sayah,Emily E. Thornton,Mark B. Headley,Tovo David,Shaun R. Coughlin,Matthew F. Krummel,Andrew D. Leavitt,Emmanuelle Passegué,Mark R. Looney +13 more
TL;DR: The lungs are identified as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.
Journal ArticleDOI
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
Emma Lefrançais,Stéphane Roga,Violette Gautier,Anne Gonzalez-de-Peredo,Bernard Monsarrat,Jean-Philippe Girard,Corinne Cayrol +6 more
TL;DR: It is proposed that the inflammatory microenvironment may exacerbate disease-associated functions of IL-33 through the generation of highly active mature forms, which are produced by activated human neutrophils ex vivo, are biologically active in vivo, and have a ∼10-fold higher activity than full-length IL- 33 in cellular assays.
Journal ArticleDOI
Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33–LacZ Gene Trap Reporter Strain
Mélanie Pichery,Emilie Mirey,Pascale Mercier,Emma Lefrançais,Arnaud Dujardin,Nathalie Ortega,Jean-Philippe Girard +6 more
TL;DR: It is found that the Il-33 promoter exhibits constitutive activity in mouse lymphoid organs, epithelial barrier tissues, brain, and embryos, supporting the possibility that IL-33 may function as a nuclear alarmin to alert the innate immune system after injury or infection in epithelial Barrier tissues.
Journal ArticleDOI
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
Emma Lefrançais,Anais Duval,Anais Duval,Emilie Mirey,Emilie Mirey,Stéphane Roga,Stéphane Roga,Eric Espinosa,Corinne Cayrol,Corinne Cayrol,Jean-Philippe Girard,Jean-Philippe Girard +11 more
TL;DR: It is found that serine proteases secreted by activated mast cells generate mature forms of IL-33 with potent activity on ILC2s, which are 30-fold more potent than full-length human IL-331–270 for activation of I LC2s ex vivo.
Journal ArticleDOI
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury
TL;DR: It is concluded that a critical balance of NETs is necessary to prevent lung injury and to maintain microbial control, which has important therapeutic implications.