G
Gary Rathbun
Researcher at Harvard University
Publications - 31
Citations - 8387
Gary Rathbun is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Gene rearrangement. The author has an hindex of 22, co-authored 31 publications receiving 8196 citations. Previous affiliations of Gary Rathbun include Columbia University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Yoichi Shinkai,Gary Rathbun,Kong-Peng Lam,E. M. Oltz,Valerie Stewart,Monica Mendelsohn,Jean Charron,Milton Datta,Faith Young,Alan M. Stall,Frederick W. Alt +10 more
TL;DR: Loss of RAG-2 function in vivo results in total inability to initiate V(D)J rearrangement, leading to a novel severe combined immune deficient (SCID) phenotype.
Journal ArticleDOI
Defective B cell development and function in Btk-deficient mice
Wasif N. Khan,Frederick W. Alt,Rachel M. Gerstein,Barbara A. Malynn,Irene Larsson,Gary Rathbun,Laurie Davidson,Sussane Müller,Aaron B. Kantor,Leonora A. Herzenberg,Fred S. Rosen,Paschalis Sideras +11 more
TL;DR: Results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development.
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A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis
Yijie Gao,Yi Sun,Karen M. Frank,Pieter Dikkes,Yuko Fujiwara,Katherine J. Seidl,JoAnn Sekiguchi,Gary Rathbun,Wojciech Swat,Jiyang Wang,Roderick T. Bronson,Barbara A. Malynn,Margaret Bryans,Chengming Zhu,Jayanta Chaudhuri,Laurie Davidson,Roger Ferrini,Thomas D. Stamato,Stuart H. Orkin,Michael E. Greenberg,Frederick W. Alt +20 more
TL;DR: These findings demonstrate that differentiating lymphocytes and neurons strictly require the XRCC4 and DNA ligase IV end-joining proteins and point to the general stage of neuronal development in which these proteins are necessary.
Journal ArticleDOI
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Karen M. Frank,JoAnn Sekiguchi,Katherine J. Seidl,Wojciech Swat,Gary Rathbun,Hwei Ling Cheng,Laurie Davidson,Landy Kangaloo,Frederick W. Alt +8 more
TL;DR: It is shown that inactivation of the ligase IV gene in mice leads to late embryonic lethality, and Ku-deficient mice are viable, so ligaseIV must also be required for processes and/or in cell types in which Ku is dispensable.
Journal ArticleDOI
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains
Lucia E. Rameh,Ann Kristin Arvidsson,Kermit L. Carraway,Anthony D. Couvillon,Gary Rathbun,Anne M. Crompton,Barbara VanRenterghem,Michael P. Czech,Kodimangalam S. Ravichandran,Steven J. Burakoff,Da Sheng Wang,Ching Shih Chen,Lewis C. Cantley +12 more
TL;DR: It is shown that the Bruton’s tyrosine kinase PH domain binds to PtdIns-3,4,5-P3 with higher affinity than to PtsdIns-4, 5-P2, Ptdins- 3,4-4-P1 or inositol 1,3, 4-5-tetrakisphosphate (Ins-1, 3, 4,5 -P4).