D
David S. Weiss
Researcher at Emory University
Publications - 142
Citations - 16860
David S. Weiss is an academic researcher from Emory University. The author has contributed to research in topics: Virulence & Innate immune system. The author has an hindex of 38, co-authored 108 publications receiving 14104 citations. Previous affiliations of David S. Weiss include New York University & Yerkes National Primate Research Center.
Papers
More filters
Journal ArticleDOI
Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
Journal ArticleDOI
Cryopyrin activates the inflammasome in response to toxins and ATP
Sanjeev Mariathasan,David S. Weiss,Kim Newton,Jacqueline McBride,Karen O'Rourke,Meron Roose-Girma,Wyne P. Lee,Yvette Weinrauch,Denise M. Monack,Vishva M. Dixit +9 more
TL;DR: It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.
Journal ArticleDOI
The apoptotic signaling pathway activated by Toll-like receptor-2.
TL;DR: It is shown that caspase activation is an innate immune response to microbial pathogens, culminating in apoptosis and cytokine production, and that TLR2 is a novel ‘death receptor’ that engages the apoptotic machinery without a conventional cytoplasmic death domain.
Journal ArticleDOI
Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
TL;DR: It is shown that wild-type Francisella, which reach the cytosol, but not Francisella mutants that remain localized to the vacuole, induced a host defense response in macrophages, which is dependent on caspase-1 and the death-fold containing adaptor protein ASC, demonstrating a key role in innate defense against infection by this pathogen.
Journal ArticleDOI
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
Timothy R. Sampson,Sunil D. Saroj,Anna C. Llewellyn,Anna C. Llewellyn,Yih-Ling Tzeng,David S. Weiss,David S. Weiss +6 more
TL;DR: It is demonstrated that the Cas protein Cas9 of Francisella novicida uses a unique, small, CRISPR/Cas-associated RNA (scaRNA) to repress an endogenous transcript encoding a bacterial lipoprotein.