Journal ArticleDOI
Magnetic Resonance Imaging–Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience
Uday B. Patel,Fiona Taylor,Lennart Blomqvist,Christopher George,Hywel Evans,Paris P. Tekkis,Philip Quirke,David Sebag-Montefiore,Brendan Moran,Richard J. Heald,Ashley Guthrie,N Bees,Ian Swift,Kjell Pennert,Gina Brown +14 more
TLDR
MRI assessment of TRG and CRM are imaging markers that predict survival outcomes for good and poor responders and provide an opportunity for the multidisciplinary team to offer additional treatment options before planning definitive surgery.Abstract:
Purpose To assess magnetic resonance imaging (MRI) and pathologic staging after neoadjuvant therapy for rectal cancer in a prospectively enrolled, multicenter study. Methods In a prospective cohort study, 111 patients who had rectal cancer treated by neoadjuvant therapy were assessed for response by MRI and pathology staging by T, N and circumferential resection margin (CRM) status. Tumor regression grade (TRG) was also assessed by MRI. Overall survival (OS) was estimated by using the Kaplan-Meier product-limit method, and Cox proportional hazards models were used to determine associations between staging of good and poor responders on MRI or pathology and survival outcomes after controlling for patient characteristics. Results On multivariate analysis, the MRI-assessed TRG (mrTRG) hazard ratios (HRs) were independently significant for survival (HR, 4.40; 95% CI, 1.65 to 11.7) and disease-free survival (DFS; HR, 3.28; 95% CI, 1.22 to 8.80). Five-year survival for poor mrTRG was 27% versus 72% (P = .001), ...read more
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Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
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High-dose chemoradiotherapy and watchful waiting for distal rectal cancer: a prospective observational study
Ane L Appelt,John Pløen,Henrik Harling,Frank Jensen,Lars Henrik Jensen,Jens Christian Riis Jørgensen,Jan Lindebjerg,Søren Rafael Rafaelsen,Anders Jakobsen +8 more
TL;DR: High-dose chemoradiotherapy and watchful waiting might be a safe alternative to abdominoperineal resection for patients with distal rectal cancer.
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EURECCA colorectal: Multidisciplinary management: European consensus conference colon & rectum
Cornelis J.H. van de Velde,Petra G. Boelens,Josep M. Borràs,Jan Willem Coebergh,Andrés Cervantes,Lennart Blomqvist,Regina G. H. Beets-Tan,Colette B.M. van den Broek,Gina Brown,Eric Van Cutsem,Eloy Espin,Karin Haustermans,Bengt Glimelius,Lene Hjerrild Iversen,J. Han van Krieken,Corrie A.M. Marijnen,Geoffrey Henning,Jola Gore-Booth,E. Meldolesi,Pawel Mroczkowski,Iris D. Nagtegaal,Peter Naredi,H. Ortiz,Lars Påhlman,Philip Quirke,Claus Rödel,Arnaud Roth,Harm J. T. Rutten,Hans J. Schmoll,J. J. Smith,Pieter J. Tanis,Claire Taylor,A. Wibe,Theo Wiggers,Maria Antonietta Gambacorta,Cynthia Aristei,Vincenzo Valentini +36 more
TL;DR: The first multidisciplinary consensus conference about cancer of the colon and rectum was held in December 2012 as mentioned in this paper, where the expert panel consisted of representatives of European scientific organisations involved in cancer care of patients with colon and Rectal cancer and representatives of national colorectal registries.
Journal ArticleDOI
Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer
Ye Yao,Xiaoya Xu,Lifeng Yang,Ji Zhu,Juefeng Wan,Lijun Shen,F. Xia,Guoxiang Fu,Yun Deng,Mengxue Pan,Qiang Guo,Xiaoxue Gao,Yuanchuang Li,Xinxin Rao,Yi Zhou,Liping Liang,Yaqi Wang,Jing Zhang,Hui Zhang,Guichao Li,Lixing Zhang,Junjie Peng,Sanjun Cai,Chen Hu,Jianjun Gao,Hans Clevers,Zhen Zhang,Guoqiang Hua +27 more
TL;DR: A living organoid biobank is generated from patients with locally advanced rectal cancer treated with neoadjuvant chemoradiation (NACR) enrolled in a phase III clinical trial to imply that PDOs predict LARC patient responses in the clinic and may represent a companion diagnostic tool inrectal cancer treatment.
Journal ArticleDOI
MR Imaging of Rectal Cancer: Radiomics Analysis to Assess Treatment Response after Neoadjuvant Therapy.
Natally Horvat,Harini Veeraraghavan,Monika Khan,Ivana Blazic,Junting Zheng,Marinela Capanu,Evis Sala,Julio Garcia-Aguilar,Marc J. Gollub,Iva Petkovska +9 more
TL;DR: T2- Weighted-based radiomics showed better classification performance compared with qualitative assessment at T2-weighted and DW imaging for diagnosing pCR in patients with locally advanced rectal cancer after CRT.
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Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Ellen Kapiteijn,Corrie A.M. Marijnen,Iris D. Nagtegaal,Hein Putter,W.H. Steup,Theo Wiggers,Harm J. T. Rutten,Lars Påhlman,Bengt Glimelius,J. Han van Krieken,J.W.H. Leer,Cornelis J.H. van de Velde +11 more
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TL;DR: In this paper, transverse slicing was used to examine whole-mount sections of the entire operative specimen of rectal adnocarcinoma and showed that the spread to the lateral resection margin in 14 of 52 (27%) patients and 12 of these proceeded to local pelvic recurrence.
Journal ArticleDOI
Pathological features of rectal cancer after preoperative radiochemotherapy
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Journal ArticleDOI
Prognostic Significance of Tumor Regression After Preoperative Chemoradiotherapy for Rectal Cancer
Claus Rödel,Peter Martus,Thomas Papadoupolos,László Füzesi,Martin Klimpfinger,Rainer Fietkau,Torsten Liersch,Werner Hohenberger,Rudolf Raab,Rolf Sauer,Christian Wittekind +10 more
TL;DR: In this exploratory analysis, complete ( TRG 4) and intermediate pathologic response (TRG 2 + 3) suggested improved DFS after preoperative CRT, and TRG assessment should be implemented in pathologic evaluation and prospectively validated in further studies.
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