D
David Shepherd
Researcher at University of Southampton
Publications - 321
Citations - 7501
David Shepherd is an academic researcher from University of Southampton. The author has contributed to research in topics: Laser & Waveguide (optics). The author has an hindex of 42, co-authored 316 publications receiving 6939 citations. Previous affiliations of David Shepherd include University of Cambridge & Bangor University.
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Journal ArticleDOI
A GAL4-Driver Line Resource for Drosophila Neurobiology
Arnim Jenett,Gerald M. Rubin,Teri-T B. Ngo,David Shepherd,Christine Murphy,Heather Dionne,Barret D. Pfeiffer,Amanda Cavallaro,Donald Hall,Jennifer Jeter,Nirmala Iyer,Dona Fetter,Joanna H. Hausenfluck,Hanchuan Peng,Eric T. Trautman,Robert Svirskas,Eugene W. Myers,Zbigniew R. Iwinski,Yoshinori Aso,Gina M. DePasquale,Adrianne Enos,Phuson Hulamm,S. Lam,Hsing-Hsi Li,Todd R. Laverty,Fuhui Long,Lei Qu,Sean D. Murphy,Konrad Rokicki,Todd Safford,Kshiti Shaw,Julie H. Simpson,Allison Sowell,Susana Tae,Yang Yu,Christopher T. Zugates +35 more
TL;DR: The utility of 7,000 transgenic lines of Drosophila melanogaster for identifying novel neuronal cell types, revealing brain asymmetry, and describing the nature and extent of neuronal shape stereotypy is illustrated.
Journal ArticleDOI
GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila.
Amritpal Mudher,David Shepherd,Tracey A. Newman,P Mildren,J P Jukes,A Squire,A Mears,S Berg,Daniel Mackay,Ayodeji A. Asuni,R Bhat,Simon Lovestone +11 more
TL;DR: The data show that tau abnormalities significantly disrupt neuronal function, in a phosphorylation-dependent manner, before the classical pathological hallmarks are evident and also suggest that the inhibition of GSK-3β might have potential therapeutic benefits in tauopathies.
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Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila.
TL;DR: An overall view of the initial connections that eventually lead to the complex connectivity of the bulk of the thoracic neurons is provided.
Journal ArticleDOI
Compact diode-pumped passively Q-switched tunable Er-Yb double-clad fiber laser.
Mathieu Laroche,A.M. Chardon,Johan Nilsson,David Shepherd,W.A. Clarkson,Sylvain Girard,Richard Moncorgé +6 more
TL;DR: Efficient repetitive passive Q switching of a cladding-pumped Er-Yb fiber laser has been demonstrated by use of an external-cavity configuration containing a Co(2+): ZnS crystal as a saturable absorber.
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Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo.
TL;DR: All these phospho-tau-mediated phenotypes occur in the absence of tau filament/neurofibrillary tangle formation or neuronal death, and may constitute the mechanism by which hyper-phosphorylated tau disrupts neuronal function and contributes to cognitive impairment prior to neuronal death in the early stages of t Tauopathies.