D
David V. Schaffer
Researcher at University of California, Berkeley
Publications - 337
Citations - 24373
David V. Schaffer is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 77, co-authored 323 publications receiving 21157 citations. Previous affiliations of David V. Schaffer include University of California & Lawrence Berkeley National Laboratory.
Papers
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Journal ArticleDOI
Substrate modulus directs neural stem cell behavior.
Krishanu Saha,Albert J. Keung,Elizabeth F. Irwin,Yang Li,Lauren Little,David V. Schaffer,Kevin E. Healy +6 more
TL;DR: This work demonstrates that the mechanical and biochemical properties of an aNSC microenvironment can be tuned to regulate the self-renewal and differentiation of aN SCs.
Journal ArticleDOI
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.
D. Gowanlock R. Tervo,Bum Yeol Hwang,Sarada Viswanathan,Thomas Gaj,Maria Lavzin,Maria Lavzin,Kimberly D. Ritola,Sarah Lindo,Susan Michael,Elena Kuleshova,Elena Kuleshova,David Stephen Ojala,Cheng Chiu Huang,Charles R. Gerfen,Charles R. Gerfen,Jackie Schiller,Jackie Schiller,Joshua T. Dudman,Adam W. Hantman,Loren L. Looger,David V. Schaffer,Alla Y. Karpova +21 more
TL;DR: A newly evolved variant of adeno-associated virus, rAAV2-retro, permits robust retrograde access to projection neurons with efficiency comparable to classical synthetic retrograde tracers and enables sufficient sensor/effector expression for functional circuit interrogation and in vivo genome editing in targeted neuronal populations.
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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
TL;DR: This work identifies Sonic hedgehog (Shh) as a regulator of adult hippocampal neural stem cells and finds high expression of the Shh receptor Patched in both the adult rat hippocampus and neural progenitor cells isolated from this region.
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Engineering adeno-associated viruses for clinical gene therapy
TL;DR: New approaches to engineer and improve AAV vectors and their genetic cargo are increasingly helping to overcome barriers to extension of clinical gene therapy successes to many other human diseases.
Journal ArticleDOI
The Influence of Hydrogel Modulus on the Proliferation and Differentiation of Encapsulated Neural Stem Cells
Akhilesh Banerjee,Manish Arha,Soumitra Choudhary,Randolph S. Ashton,Surita R. Bhatia,David V. Schaffer,Ravi S. Kane +6 more
TL;DR: This work describes studies of the proliferation and differentiation of neural stem cells encapsulated within three-dimensional scaffolds--alginate hydrogels--whose elastic moduli were varied over two orders of magnitude.