D
David Vilchez
Researcher at University of Cologne
Publications - 54
Citations - 2981
David Vilchez is an academic researcher from University of Cologne. The author has contributed to research in topics: Proteostasis & Induced pluripotent stem cell. The author has an hindex of 21, co-authored 43 publications receiving 2390 citations. Previous affiliations of David Vilchez include Salk Institute for Biological Studies & University of Barcelona.
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Journal ArticleDOI
The role of protein clearance mechanisms in organismal ageing and age-related diseases
TL;DR: Modulation of either proteasome activity or autophagic-lysosomal potential extends lifespan and protects organisms from symptoms associated with proteostasis disorders, suggesting that protein clearance mechanisms are directly linked to ageing and age-associated diseases.
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RPN-6 determines C. elegans longevity under proteotoxic stress conditions
David Vilchez,Ianessa Morantte,Zheng Liu,Peter M. Douglas,Carsten Merkwirth,Ana P. C. Rodrigues,Ana P. C. Rodrigues,Gerard Manning,Gerard Manning,Andrew Dillin +9 more
TL;DR: It is found that the forced re-investment of resources from the germ line to the soma in Caenorhabditis elegans results in elevated somatic proteasome activity, clearance of damaged proteins and increased longevity.
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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.
David Vilchez,Leah Boyer,Ianessa Morantte,Margaret Lutz,Carsten Merkwirth,Derek Joyce,Brian Spencer,Lesley J. Page,Eliezer Masliah,W. Travis Berggren,Fred H. Gage,Andrew Dillin +11 more
TL;DR: The results suggest a new regulation of proteostasis in hESCs that links longevity and stress resistance in invertebrates to hESC function and identity and that is correlated with increased levels of the 19S proteasome subunit PSMD11.
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Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy.
David Vilchez,Susana Ros,Daniel Cifuentes,Lluís Pujadas,Jordi Vallès,Belén García-Fojeda,Olga Criado-García,E. Fernández-Sánchez,Iria Medraño-Fernández,Jorge Domínguez,Mar García-Rocha,Eduardo Soriano,Santiago Rodríguez de Córdoba,Joan J. Guinovart +13 more
TL;DR: It is shown that mouse neurons have the enzymatic machinery for synthesizing glycogen, but that it is suppressed by retention of muscle glycogen synthase in the phosphorylated, inactive state, and that the malin-laforin complex ensures a blockade of neuronal glycogen synthesis even under intense glycogenic conditions.
Journal ArticleDOI
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
Isabel Saez,David Vilchez +1 more
TL;DR: Modulation of proteasomesome activity extends lifespan and protects organisms from symptoms associated with proteostasis disorders, and strategies to modulate proteasome activity and delay the onset of diseases associated to proteasomal dysfunction are discussed herein.