D
David Voehringer
Researcher at University of Erlangen-Nuremberg
Publications - 127
Citations - 10280
David Voehringer is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Immune system & Immunoglobulin E. The author has an hindex of 41, co-authored 111 publications receiving 8481 citations. Previous affiliations of David Voehringer include University of California, San Francisco & University of Freiburg.
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Journal ArticleDOI
Swiprosin‐1/EFhd2 limits germinal center responses and humoral type 2 immunity
Sebastian Brachs,Adriana Turqueti-Neves,Merle Stein,Dorothea Reimer,Bent Brachvogel,Michael R. Bösl,Thomas Winkler,David Voehringer,Hans-Martin Jäck,Dirk Mielenz +9 more
TL;DR: A role is established for EFhd2 as a negative regulator of germinal center‐dependent humoral type 2 immunity, with implications for the generation of IgE.
Journal ArticleDOI
IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis.
Wolger Lübben,Adriana Turqueti-Neves,Anna Okhrimenko,Christian Stöberl,Volker Schmidt,Klaus Pfeffer,Sonja Dehnert,Sarah Wünsche,Silke Storsberg,Stefanie Paul,Stefan Bauer,Gert Riethmüller,David Voehringer,Philipp Yu +13 more
TL;DR: It is proposed that an enhanced, antigen‐specific, polyclonal IgE response, as is the case in allergic patients, is probably the most efficient way to sensitize basophils to contribute to systemic anaphylaxis in vivo.
Journal ArticleDOI
Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains.
Alex Steimle,Sarah Menz,Annika Bender,Brianna Ball,Alexander N.R. Weber,Thomas Hagemann,Anna Lange,Jan K. Maerz,Raphael Parusel,Lena Michaelis,Andrea I. Schäfer,Hans Yao,Hanna-Christine Löw,Sina Beier,Mehari Tesfazgi Mebrhatu,Kerstin Gronbach,Samuel Wagner,David Voehringer,Martin Schaller,Birgit Fehrenbacher,Ingo B. Autenrieth,Tobias A. Oelschlaeger,Julia-Stefanie Frick +22 more
TL;DR: Flagellin from symbiotic E. coli strains is proposed as a potential therapeutic to restore intestinal immune homeostasis, e.g., for the treatment of IBD patients.
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Selective expression of constitutively activated STAT6 in intestinal epithelial cells promotes differentiation of secretory cells and protection against helminths.
Christoph Schubart,Branislav Krljanac,Manuel Otte,Cornelia Symowski,Eva Martini,Claudia Günther,Christoph Becker,Christoph Daniel,David Voehringer +8 more
TL;DR: An important IEC-intrinsic role of STAT6-regulated genes for intestinal homeostasis and protective immunity against helminths is revealed.
Journal ArticleDOI
Accumulation of Effector CD4 T Cells during Type 2 Immune Responses Is Negatively Regulated by Stat6
TL;DR: Functional analysis of Th2 memory cells revealed that Stat6 signaling in CD4 T cells was dispensable for memory cell generation, expansion, and cytokine secretion, and Stat6-deficient T cells survived better than wild-type T cells, resulting in higher accumulation in the bronchoalveolar lavage and lymph nodes.