D
David W. Gaylor
Researcher at University of Arkansas for Medical Sciences
Publications - 9
Citations - 3174
David W. Gaylor is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Autism & Transsulfuration. The author has an hindex of 9, co-authored 9 publications receiving 3011 citations. Previous affiliations of David W. Gaylor include Boston Children's Hospital.
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Journal ArticleDOI
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
S. Jill James,Paul Cutler,Stepan Melnyk,Stefanie Jernigan,Laurette Janak,David W. Gaylor,James Neubrander +6 more
TL;DR: An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
Journal ArticleDOI
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
S. Jill James,Stepan Melnyk,Stefanie Jernigan,Mario A. Cleves,Charles H. Halsted,Donna H. Wong,Paul Cutler,Kenneth Bock,Marvin Boris,James Jeffrey Bradstreet,Sidney M. Baker,David W. Gaylor +11 more
TL;DR: It is proposed that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism.
Letter to the Editor Metabolic Endophenotype and Related Genotypes are Associated With Oxidative Stress in Children With Autism
S. Jill James,Stepan Melnyk,Stefanie Jernigan,Mario A. Cleves,Charles H. Halsted,Donna H. Wong,Paul Cutler,Kenneth Bock,Marvin Boris,Sidney M. Baker,David W. Gaylor +10 more
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Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
S. Jill James,Marta Pogribna,Igor P. Pogribny,Stepan Melnyk,R. Jean Hine,James B. Gibson,Ping Yi,Dixie L Tafoya,David H Swenson,Vincent L Wilson,David W. Gaylor +10 more
TL;DR: In this paper, the C-to-T substitution at nucleotide 677 (677C→T) mutation of the methylenetetrahydrofolate reductase (MTHFR) gene may be a risk factor for maternal meiotic nondisjunction and Down syndrome in young mothers.
Journal ArticleDOI
Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
Stepan Melnyk,Stepan Melnyk,George J. Fuchs,George J. Fuchs,Eldon G. Schulz,Eldon G. Schulz,Maya Lopez,Maya Lopez,Stephen G. Kahler,Stephen G. Kahler,Jill J. Fussell,Jill J. Fussell,Jayne Bellando,Jayne Bellando,Oleksandra Pavliv,Oleksandra Pavliv,Shannon Rose,Shannon Rose,Lisa Seidel,Lisa Seidel,David W. Gaylor,S. Jill James,S. Jill James +22 more
TL;DR: The data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression, and suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism.