S
Stepan Melnyk
Researcher at University of Arkansas for Medical Sciences
Publications - 134
Citations - 10560
Stepan Melnyk is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Oxidative stress & DNA methylation. The author has an hindex of 47, co-authored 129 publications receiving 9705 citations. Previous affiliations of Stepan Melnyk include Boston Children's Hospital & National Center for Toxicological Research.
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Journal ArticleDOI
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
S. Jill James,Paul Cutler,Stepan Melnyk,Stefanie Jernigan,Laurette Janak,David W. Gaylor,James Neubrander +6 more
TL;DR: An increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
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Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*
Ping Yi,Stepan Melnyk,Marta Pogribna,Igor P. Pogribny,R. Jean Hine,S. Jill James,S. Jill James +6 more
TL;DR: Chronic elevation in plasma homocysteine levels, such as those associated with nutritional deficiencies or genetic polymorphisms in the folate pathway, may have an indirect and negative effect on cellular methylation reactions through a concomitant increase in intracellular SAH levels.
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Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition
Zhoutao Chen,Andrew C. Karaplis,Susan L. Ackerman,Igor P. Pogribny,Stepan Melnyk,Suzanne Lussier-Cacan,Moy Fong Chen,Aditya Pai,Simon W. M. John,Richard S. Smith,Teodoro Bottiglieri,Pamela J. Bagley,Jacob Selhub,Michael A. Rudnicki,S. Jill James,Rima Rozen +15 more
TL;DR: Abnormal lipid deposition in the proximal portion of the aorta was observed in older heterozygotes and homozygotes, alluding to an atherogenic effect of hyperhomocysteinemia in these mice.
Journal ArticleDOI
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism
S. Jill James,Stepan Melnyk,Stefanie Jernigan,Mario A. Cleves,Charles H. Halsted,Donna H. Wong,Paul Cutler,Kenneth Bock,Marvin Boris,James Jeffrey Bradstreet,Sidney M. Baker,David W. Gaylor +11 more
TL;DR: It is proposed that an increased vulnerability to oxidative stress (endogenous or environmental) may contribute to the development and clinical manifestations of autism.
Letter to the Editor Metabolic Endophenotype and Related Genotypes are Associated With Oxidative Stress in Children With Autism
S. Jill James,Stepan Melnyk,Stefanie Jernigan,Mario A. Cleves,Charles H. Halsted,Donna H. Wong,Paul Cutler,Kenneth Bock,Marvin Boris,Sidney M. Baker,David W. Gaylor +10 more