D
David Whitmore
Researcher at University College London
Publications - 65
Citations - 3406
David Whitmore is an academic researcher from University College London. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 29, co-authored 62 publications receiving 3049 citations. Previous affiliations of David Whitmore include French Institute of Health and Medical Research & Max Planck Society.
Papers
More filters
Journal ArticleDOI
Light acts directly on organs and cells in culture to set the vertebrate circadian clock.
TL;DR: It is shown that the peripheral organ clocks of zebra fish are set by light–dark cycles in culture and that a zebrafish-derived cell line contains a circadian oscillator, which is also directly light entrained.
Journal ArticleDOI
Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators
TL;DR: Cloned Clock in zebrafish shows that, in contrast to its mouse homologue, it is expressed with a pronounced circadian rhythm in the brain and in two defined pacemaker structures, the eye and the pineal gland, demonstrating that self-sustaining circadian oscillators exist in several vertebrate organs, as was previously reported for invertebrates.
Journal ArticleDOI
Light Regulates the Cell Cycle in Zebrafish
Marcus P. S. Dekens,Cristina Santoriello,Daniela Vallone,Gabriele Grassi,David Whitmore,Nicholas S. Foulkes +5 more
TL;DR: It is demonstrated that light plays a key role in cell cycle regulation in the zebrafish, and the cell-autonomous circadian clock is implicate in the regulation of the vertebrate cell cycle by light.
Journal ArticleDOI
Light signaling to the zebrafish circadian clock by Cryptochrome 1a
TL;DR: It is shown that Cryptochrome 1a (Cry1a) plays a key role in light entrainment of the zebrafish clock, leading not only to entrainedment, but also to the establishment of a high-amplitude rhythm and even stopping of the clock under long photoperiods.
Journal ArticleDOI
E-box function in a period gene repressed by light
TL;DR: The cloning of a zebrafish per gene, zfper4, which is remarkable in being repressed by light is reported, and flexibility in the phase and light responsiveness of E-box-directed rhythmic expression, depending on the promoter context is revealed.