D
Davide Chiarugi
Researcher at University of Cambridge
Publications - 47
Citations - 695
Davide Chiarugi is an academic researcher from University of Cambridge. The author has contributed to research in topics: Lipid metabolism & Medicine. The author has an hindex of 12, co-authored 41 publications receiving 435 citations. Previous affiliations of Davide Chiarugi include University of Pisa & Max Planck Society.
Papers
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Journal ArticleDOI
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
Alice E. Adriaenssens,Emma K Biggs,Tamana Darwish,John Tadross,Tanmay Sukthankar,Milind Girish,Joseph Polex-Wolf,Brain Y Lam,Ilona Zvetkova,Warren Pan,Davide Chiarugi,Giles Sh Yeo,Clemence Blouet,Fiona M. Gribble,Frank Reimann +14 more
TL;DR: These data identify hypothalamic GIPR as a target for the regulation of energy balance and identify central mediators of this effect.
Journal ArticleDOI
Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
Geoffrey P. Roberts,Pierre Larraufie,Paul Richards,Paul Richards,Richard G. Kay,Sam G Galvin,Emily L. Miedzybrodzka,Andrew B. Leiter,Joyce Li,Leslie L Glass,Marcella Ma,Brian Y.H. Lam,Giles S.H. Yeo,Raphael Scharfmann,Davide Chiarugi,Richard H. Hardwick,Frank Reimann,Fiona M. Gribble +17 more
TL;DR: The transcriptomic and peptidomic profiles of human and mouse EECs and cross-species comparison will be valuable tools for drug discovery programs and for understanding human metabolism and the endocrine impacts of bariatric surgery.
Journal ArticleDOI
Quantitative assessment of ribosome drop-off in E. coli
TL;DR: It is shown that a significant rate of ribosome drop-off is measurable and can be quantified also when cells are cultured under non-stressing conditions, and that the drop-offs rate is highly variable, depending on multiple factors.
Journal ArticleDOI
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma
Zoe Hall,Zoe Hall,Davide Chiarugi,Evelina Charidemou,Jack Leslie,Emma Scott,Luca Pellegrinet,Michael Allison,Gabriele Mocciaro,Quentin M. Anstee,Quentin M. Anstee,Gerard I. Evan,Matthew Hoare,Antonio Vidal-Puig,Fiona Oakley,Michele Vacca,Michele Vacca,Julian L. Griffin,Julian L. Griffin +18 more
TL;DR: In order to capture the metabolic signature of proliferating hepatocytes, state-of-the-art systems biology approaches are applied to models of liver regeneration, pharmacologically and genetically activated cell proliferation, and HCC.
Book ChapterDOI
VICE: a VIrtual CEll
TL;DR: The results of the experimentation in silico confirm that the virtual cell “survives” in an optimal environment and shows a behaviour similar to that of real prokaryotes.