J
John Tadross
Researcher at University of Cambridge
Publications - 30
Citations - 919
John Tadross is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 20 publications receiving 467 citations. Previous affiliations of John Tadross include Imperial College London & Cambridge University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
GDF15 mediates the effects of metformin on body weight and energy balance
Anthony P. Coll,Michael Chen,Pranali Taskar,Debra Rimmington,Satish Patel,John Tadross,Irene Cimino,Ming Yang,Paul Welsh,Sam Virtue,Deborah A. Goldspink,Emily L. Miedzybrodzka,Adam R. Konopka,Raul Ruiz Esponda,Jeffrey T.-J. Huang,Y. C. Loraine Tung,Sergio Rodriguez-Cuenca,Rute A. Tomaz,Heather P. Harding,Audrey Melvin,Giles S.H. Yeo,David Preiss,Antonio Vidal-Puig,Ludovic Vallier,K. Sreekumaran Nair,Nicholas J. Wareham,David Ron,Fiona M. Gribble,Frank Reimann,Naveed Sattar,David B. Savage,Bernard B. Allan,Stephen O'Rahilly +32 more
TL;DR: It is shown—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.
Journal ArticleDOI
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
Alice E. Adriaenssens,Emma K Biggs,Tamana Darwish,John Tadross,Tanmay Sukthankar,Milind Girish,Joseph Polex-Wolf,Brain Y Lam,Ilona Zvetkova,Warren Pan,Davide Chiarugi,Giles Sh Yeo,Clemence Blouet,Fiona M. Gribble,Frank Reimann +14 more
TL;DR: These data identify hypothalamic GIPR as a target for the regulation of energy balance and identify central mediators of this effect.
Journal ArticleDOI
The mechanisms of weight loss after bariatric surgery
John Tadross,C. W. le Roux +1 more
TL;DR: The physiology of energy balance and the putative mechanisms of change in weight set point following bariatric surgical procedures such as Roux-en-Y gastric bypass and adjustable gastric banding are described.
Journal ArticleDOI
Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome
Joseph Polex-Wolf,Brian Y H Lam,Rachel Larder,John Tadross,Debra Rimmington,Fatima Bosch,Verónica Jiménez Cenzano,Eduard Ayuso,Marcella Ma,Kara Rainbow,Anthony P. Coll,Stephen O'Rahilly,Giles S.H. Yeo +12 more
TL;DR: It is shown that selective disruption of Snord116 expression in the mediobasal hypothalamus models the hyperphagia of Prader-Willi syndrome.
Journal ArticleDOI
Alarin stimulates food intake and gonadotrophin release in male rats
Charlotte K. Boughton,Michael Patterson,Gavin A. Bewick,John Tadross,James Gardiner,Kylie Beale,F. Chaudery,G. Hunter,Mark Busbridge,E. M. Leavy,M. A. Ghatei,S.R. Bloom,Kevin Murphy +12 more
TL;DR: The effects of alarin on food intake and gonadotrophin release are investigated in rats by encoding a splice variant of galanin‐like peptide (GALP) mRNA.