R
Richard H. Hardwick
Researcher at Cambridge University Hospitals NHS Foundation Trust
Publications - 56
Citations - 3433
Richard H. Hardwick is an academic researcher from Cambridge University Hospitals NHS Foundation Trust. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 24, co-authored 52 publications receiving 2725 citations. Previous affiliations of Richard H. Hardwick include University of Cambridge.
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Journal ArticleDOI
Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research
Rebecca C. Fitzgerald,Richard H. Hardwick,David G. Huntsman,Fátima Carneiro,Parry Guilford,Vanessa Blair,Daniel C. Chung,Jeffrey A. Norton,Krishnadath Ragunath,J. Han van Krieken,Sarah Dwerryhouse,Carlos Caldas +11 more
TL;DR: A multidisciplinary workshop was convened to discuss genetic testing, surgery, endoscopy and pathology reporting, and updated recommendations include broadening of CDH1 testing criteria such that histological confirmation of diffuse gastric criteria is only required for one family member.
Journal ArticleDOI
Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
Rachel S. van der Post,Ingrid P. Vogelaar,Fátima Carneiro,Parry Guilford,David G. Huntsman,Nicoline Hoogerbrugge,Carlos Caldas,Karen E Chelcun Schreiber,Richard H. Hardwick,Margreet G. E. M. Ausems,Linda Bardram,Patrick R. Benusiglio,Tanya M. Bisseling,Vanessa Blair,Eveline M. A. Bleiker,Alex Boussioutas,Annemieke Cats,Daniel G. Coit,Lynn DeGregorio,Joana Figueiredo,James M. Ford,Esther Heijkoop,Rosella P.M.G. Hermens,Bostjan Humar,Pardeep Kaurah,G. Keller,Jennifer Lai,Marjolijn J. L. Ligtenberg,Maria O'Donovan,Carla Oliveira,Hugo Pinheiro,Krish Ragunath,Esther Rasenberg,Susan Richardson,Franco Roviello,Hans K. Schackert,Raquel Seruca,Amy E Taylor,Anouk ter Huurne,Marc Tischkowitz,Sheena Tjon A Joe,Benjamin van Dijck,Nicole C.T. van Grieken,Richard van Hillegersberg,Johanna W. van Sandick,Rianne Vehof,J. Han van Krieken,Rebecca C. Fitzgerald +47 more
TL;DR: The updated guidelines include revised CDH1 testing criteria, which could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma.
Journal ArticleDOI
Benchmarking Complications Associated with Esophagectomy.
Donald E. Low,Madhan Kumar Kuppusamy,Derek Alderson,Ivan Cecconello,Andrew C. Chang,Gail Darling,Andrew Davies,Xavier Benoit D’Journo,Suzanne S. Gisbertz,S. Michael Griffin,Richard H. Hardwick,Arnulf H. Hoelscher,Wayne L. Hofstetter,Blair A. Jobe,Yuko Kitagawa,Simon Law,Christophe Mariette,Nick Maynard,Christopher R. Morse,Philippe Nafteux,Manuel Pera,C S Pramesh,Sonia Puig,John V. Reynolds,Wolfgang Schroeder,Mark Smithers,Bas P. L. Wijnhoven +26 more
TL;DR: Standardized methods provide contemporary international benchmarks for reporting outcomes after esophagectomy, using a standardized dataset with specific definitions to prospectively collect international data to provide a benchmark for complications and outcomes associated with esphagectomy.
Journal ArticleDOI
Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
Jamie M J Weaver,Caryn S. Ross-Innes,Nicholas B. Shannon,Andy G. Lynch,Tim Forshew,Mariagnese Barbera,Muhammed Murtaza,Chin-Ann Johnny Ong,Pierre Lao-Sirieix,Mark J Dunning,Laura Smith,Mike L. Smith,Charlotte Anderson,Benilton S. Carvalho,Maria O'Donovan,Timothy J. Underwood,Andrew May,Nicola Grehan,Richard H. Hardwick,Jim Davies,Arusha Oloumi,Samuel Aparicio,Carlos Caldas,Matthew D. Eldridge,Paul A.W. Edwards,Nitzan Rosenfeld,Simon Tavaré,Rebecca C. Fitzgerald +27 more
TL;DR: In conclusion, mutations in EAC driver genes generally occur exceptionally early in disease development with profound implications for diagnostic and therapeutic strategies.
Journal ArticleDOI
Acceptability and accuracy of a non-endoscopic screening test for Barrett’s oesophagus in primary care: cohort study
Sudarshan R. Kadri,Pierre Lao-Sirieix,Maria O'Donovan,Irene Debiram,Madhumita Das,Jane M Blazeby,Jon Emery,Alex Boussioutas,Helen C. Morris,Fiona M Walter,Paul D.P. Pharoah,Richard H. Hardwick,Rebecca C. Fitzgerald +12 more
TL;DR: The performance of the Cytosponge test was promising and the procedure was well tolerated, bringing screening for Barrett’s oesophagus into the realm of possibility.