Davide Zella

TL;DR: The findings suggest that the virus is evolving and European, North American and Asian strains might coexist, each of them characterized by a different mutation pattern.

TL;DR: The structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX is deciphered, shedding new light on structure-based rational design of different classes of p 53 activators for potential therapeutic use.

TL;DR: Low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages and identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.

TL;DR: The ability of TRAIL to promote the survival/proliferation of endothelial cells without inducing NF-&kgr;B activation and inflammatory markers suggests that the TRAIL/TRAIL-R system plays an important role in endothelial cell physiology.

TL;DR: The data indicate a potentially important role for extracellular Tat in rendering bystander CD4+ T cells more susceptible to infection with X4-tropic HIV-1 isolates.