Assunta Pandolfi

TL;DR: The ability of TRAIL to promote the survival/proliferation of endothelial cells without inducing NF-&kgr;B activation and inflammatory markers suggests that the TRAIL/TRAIL-R system plays an important role in endothelial cell physiology.

TL;DR: The indication from cohort studies that there is an association between oxLDL and cardiovascular (CV) events seems to point toward a role for ox LDL in atherosclerotic plaque progress and disruption, but randomized clinical trials using antioxidants have demonstrated benefits only in high-risk patients, suggesting that additional proofs are still needed to better define the involvement of each type of modified LDL in the development of atherosclerosis.

TL;DR: The data demonstrate that, possibly via a direct interaction with the endothelial thrombospondin‐(αvβ3) integrin complex, ESRD‐RBC‐HUVEC adhesion induces a vascular inflammatory phenotype, and intervention targeting ESRRBC increased adhesion to endothelium and/or MAPK and Akt/eNOS pathways may have the potential to prevent vascular lesions under uremic conditions.

TL;DR: The results indicate that GCs from older patients suffer from age-dependent oxidative stress injury and are taken as an evidence for reduced defence against reactive oxygen species (ROS) in GCs during reproductive ageing.

TL;DR: Evidence is provided that diabetes is associated with increased PAI-1 in the arterial wall, which might be an important factor for increased cardiovascular risk and unfavorable plaque evolution in diabetes.