Davina Wu

TL;DR: It is shown that eosinophils are the major IL-4–expressing cells in white adipose tissues of mice, and, in their absence, AAMs are greatly attenuated.

TL;DR: The contribution of basophils to allergic and helminth immunity remains unclear as discussed by the authors, and Locksley et al. used reporter strains and two-photon microscopy to demonstrate that basophilia does not mediate T helper type 2 priming in vivo.

TL;DR: It is demonstrated that the IL-4/STAT6 immune axis, a key pathway in helminth immunity and allergies, controls peripheral nutrient metabolism and insulin sensitivity, and an unexpected molecular link between the immune system and macronutrient metabolism is identified.

TL;DR: It is shown that only IL-5 induces differentiation of eosinophils from bone marrow precursors, whereas IL- 5, GM-CSF, and to a lesser extent IL-3 promote survival of mature eos inophils, suggesting that therapeutic strategies targeting Bcl-xL in eosInophils could improve health conditions in allergic inflammatory diseases.

TL;DR: The strategy of ES cell cultures in replicate plates proved to be very efficient in identifying ES cells that had undergone the correct recombination event and facilitates the generation of conditional knock-out mice when large parts of the genome are intended to be flanked by loxP sites.