Roberto R. Ricardo-Gonzalez

TL;DR: It is shown that mice with macrophage-specific deletion of the peroxisome proliferator activated receptor-γ (PPARγ) are required for maturation of alternatively activated macrophages, and gene expression profiling revealed that downregulation of oxidative phosphorylation gene expression in skeletal muscle and liver leads to decreased insulin sensitivity in these tissues.

TL;DR: It is shown that eosinophils are the major IL-4–expressing cells in white adipose tissues of mice, and, in their absence, AAMs are greatly attenuated.

TL;DR: It is shown that in response to the Th2 cytokine interleukin-4 (IL-4), peroxisome proliferator-activated receptor delta (PPARdelta) directs expression of the alternative phenotype in Kupffer cells and adipose tissue macrophages of lean mice, suggesting an unexpected beneficial role for alternatively activated K upffer cells in metabolic syndrome and type 2 diabetes.

TL;DR: It is demonstrated that Tregs in skin play a major role in HF biology by promoting the function of HF SCs and expression of Jag1 facilitated HFSC function and efficient HF regeneration.

TL;DR: PPAR-δ has a pivotal role in orchestrating the timely disposal of apoptotic cells by macrophages, ensuring that tolerance to self is maintained.