D
Davit A. Potoyan
Researcher at Iowa State University
Publications - 55
Citations - 1342
Davit A. Potoyan is an academic researcher from Iowa State University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 17, co-authored 44 publications receiving 884 citations. Previous affiliations of Davit A. Potoyan include University of Maryland, College Park & University of North Carolina at Chapel Hill.
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Phase transition of RNA-protein complexes into ordered hollow condensates.
Ibraheem Alshareedah,Mahdi Muhammad Moosa,Muralikrishna Raju,Davit A. Potoyan,Priya R. Banerjee +4 more
TL;DR: The findings suggest that protein−RNA complexes can robustly create lipid-free vesicle-like enclosures by phase separation, and suggest that liquid−liquid phase separation of multivalent intrinsically disordered protein− RNA complexes is ubiquitous in both natural and biomimetic systems.
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Anomalous diffusion, spatial coherence, and viscoelasticity from the energy landscape of human chromosomes
TL;DR: It is demonstrated that the very same interactions that account for genome architecture naturally reproduce the spatial coherence, viscoelasticity, and the subdiffusive behavior of the motion in interphase chromosomes as observed in numerous experiments.
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Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies.
Taranpreet Kaur,Muralikrishna Raju,Ibraheem Alshareedah,Richoo B. Davis,Davit A. Potoyan,Priya R. Banerjee +5 more
TL;DR: In this paper, a ternary system comprising of a prion-like polypeptide (PLP), arginine-rich polypeptic (RRP), and RNA was used to demix the two types of biomolecular condensates into stable coexisting phases.
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Energy landscape analyses of disordered histone tails reveal special organization of their conformational dynamics.
TL;DR: This work rationalized observed patterns of conformational dynamics of various histone tails using ideas from physics of polyelectrolytes and disordered systems, and discovered an intriguing re-entrant contraction-expansion of the tails upon heating, which is caused by subtle interplay between ionic screening and chain entropy.
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Recent successes in coarse‐grained modeling of DNA
TL;DR: The aim is to review the existing CG models of the double‐stranded DNA, where a small selection of models, which are believed to provide avenues for promising future development, are discussed in some detail.