D
Daxesh P. Patel
Researcher at National Institutes of Health
Publications - 40
Citations - 451
Daxesh P. Patel is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Selected reaction monitoring & High-performance liquid chromatography. The author has an hindex of 11, co-authored 34 publications receiving 316 citations. Previous affiliations of Daxesh P. Patel include Fuzhou University & Gujarat University.
Papers
More filters
Journal ArticleDOI
Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.
Daxesh P. Patel,Kristopher W. Krausz,Cen Xie,Diren Beyoğlu,Frank J. Gonzalez,Jeffrey R. Idle,Jeffrey R. Idle +6 more
TL;DR: A novel, selective and sensitive single-ion monitoring (SIM) gas chromatography-mass spectrometry (GCMS) method was developed and validated for the determination of energy metabolites related to glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis), and fatty acid β-oxidation.
Journal ArticleDOI
Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.
Chirag N. Patel,John J. Georrge,Krunal Modi,Moksha B. Narechania,Daxesh P. Patel,Frank J. Gonzalez,Himanshu A. Pandya +6 more
TL;DR: This study identified the potential COMT inhibitors through pharmacophore-based inhibitor screening leading to a more complete understanding of molecular-level interactions.
Journal ArticleDOI
Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.
Chad Brocker,Daxesh P. Patel,Thomas J. Velenosi,Donghwan Kim,Tingting Yan,Jiang Yue,Guolin Li,Kristopher W. Krausz,Frank J. Gonzalez +8 more
TL;DR: Extrahepatic PPARA activity reduces systemic lipid load when hepatic lipid metabolism is impaired by elevating FAO and lipase activity in other tissues and, as a result, protects against fasting-induced hepatosteatosis.
Journal ArticleDOI
Metabolic alterations in triptolide-induced acute hepatotoxicity.
Jie Zhao,Jie Zhao,Cen Xie,Xiyan Mu,Kristopher W. Krausz,Daxesh P. Patel,Xiaowei Shi,Xiaoxia Gao,Qiao Wang,Frank J. Gonzalez +9 more
TL;DR: New mechanistic insights are provided into the metabolic alterations that lead to triptolide-induced hepatotoxicity and the mechanism is related to alterations in multiple metabolic pathways.
Journal ArticleDOI
Challenges in the simultaneous quantitation of sumatriptan and naproxen in human plasma: Application to a bioequivalence study
TL;DR: The UPLC-MS/MS method was applied to support a bioequivalence study of 85 mg sumatriptan+500 mg naproxen sodium fixed dose formulation in 28 healthy Indian subjects and reproducibility was demonstrated by reanalysis of 123 incurred samples.