Showing papers in "Journal of Lipid Research in 2018"

TL;DR: A community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal is initiated.

TL;DR: This review will highlight the role of the various lipidic pathways involved in the biogenesis and functions of microvesicles and exosomes in intercellular communication mediated by extracellular vesicles.

TL;DR: CD36’s role in facilitating cellular long-chain fatty acid uptake across the plasma membrane is reviewed, particularly in heart and skeletal muscles, to identify metabolic targets to manipulate the cellular utilization of fatty acids.

TL;DR: The present findings suggest that converted enlarged brown adipocytes are highly prone to death, which, by promoting inflammation in whitened BAT, may contribute to the typical inflammatory state seen in obesity.

TL;DR: It is described how acid and neutral SMases, by generating the constitutive SL, ceramide, facilitate biogenesis of EVs at the plasma membrane and inside the endocytic compartment.

TL;DR: Data show that SREBP-1c and ChREBP are both required for coordinated induction of glycolytic and lipogenic mRNAs, and overlapping, but distinct, actions ensure that the liver synthesizes FAs only when insulin and carbohydrates are both present.

TL;DR: It is proposed that increased levels of cardiolipin and ubiquinone may help to preserve mitochondrial function in early NAFLD, but that mitochondrial function eventually fails with progression to NASH, leading to increased acylcarnitine.

TL;DR: The reported roles of eicosanoids conveyed by EVs are reviewed and their potential as biomarkers are described, including modulation of distal immune responses.

TL;DR: This review focuses on current understanding of the structure-function relationships of human ABCA1 and the molecular mechanisms underlying HDL particle production.

TL;DR: The data together show the circulating ceramide lipids investigated here are associated with adverse cardiac outcome during long-term follow-up independent of clinical risk factors.

TL;DR: Findings in this network meta-analysis are in line with existing evidence on the metabolic effects of fat and support current recommendations to replace high saturated-fat food with unsaturated oils.

TL;DR: Characteristics of the selective uptake pathway and involvement of microvillar channels as facilitators of selective HDL-CE uptake are summarized and the potential mechanisms of SR-B1-mediated selective cholesterol transport are presented.

TL;DR: Downregulation of both BDH1 and OXCT1 rendered HeLa cells sensitive to the KD in vitro and in vivo, suggesting that tumors with low ketolytic enzyme expression may be unable to metabolize ketone bodies, thus predicting a better response to KD therapy.

TL;DR: Evidence for cholesterol accumulation in EVs is compiled and its possible contribution to their biogenesis, release, and uptake is discussed and potential implications in cellular sterol homeostasis and in cholesterol-related diseases are considered.

TL;DR: This work has proposed a practical methodology for widely targeted quantitative lipidome analysis using supercritical fluid chromatography fast-scanning triple-quadrupole mass spectrometry (SFC/QqQMS) and theoretically calculated a comprehensive lipid multiple reaction monitoring (MRM) library.

TL;DR: W Whole-transcriptome analysis demonstrated that development was impaired in the Sandhoff disease organoids, suggesting that alterations in neuronal differentiation may occur during early development in the GM2 gangliosidoses.

TL;DR: The current understanding of the different steps in the assembly of B-lps is summarized and the role of lipid transfer proteins in these steps is discussed to help identify new clinical targets for lipid-associated disorders, such as heart disease.

TL;DR: This Thematic Review focuses on the relationship between Lp(a), chronic kidney disease, and risk of cardiovascular events.

TL;DR: C citrus flavonoid supplementation to a HFHC diet reversed existing obesity and adipocyte size and number through enhanced energy expenditure and increased hepatic fatty acid oxidation, and resulted in atherosclerotic lesions that were unchanged in size, but characterized by reduced macrophage content, consistent with a more stable plaque phenotype.

TL;DR: AiPLA2 is a Ca2+-independent intracellular phospholipase A2 that is localized to cytosol, lysosomes, and Lysosomal-related organelles as discussed by the authors.

TL;DR: The current status of LTP research is presented with a focus on the role of these proteins in lipid barrier deposition and cell expansion, and it is suggested that LTPs facilitate extracellular transfer of barrier materials and adhesion between barriers andextracellular materials.

TL;DR: The purpose of this review will be to summarize the current state of knowledge, but also highlight key conceptual and mechanistic issues that remain to be explored.

TL;DR: The data demonstrate for the first time the indispensable role of EPT1 in the myelination process and neurodevelopment, and in the maintenance of normal homeostasis of ether-linked phospholipids in humans.

TL;DR: This study revealed that the miR-103/107-Wnt3a/β-catenin-ATF6 pathway is critical to the progression of apoptosis in preadipocytes, which suggested that approaches to activate miR/107 could potentially be useful as new therapies for treating obesity and metabolic syndrome-related disorders.

TL;DR: This review compares several LTP-mediated inter-organelle lipid trafficking systems and proposes that LTPs generate unidirectional fluxes of specific lipids between different organelles by indirect coupling with the metabolic reactions that occur in specificorganelles.

TL;DR: This review aims to recapitulate the current knowledge of the role of PLD2 and its product, phosphatidic acid, in the biogenesis of exosomes and to propose hypotheses for further investigation of a possible central role of these molecules in the biology of these organelles.

TL;DR: The structure of CETP and its mechanism of action are described, details of its regulation and nonlipid transporting functions are discussed, and the results of the large scale clinical outcome trials of small molecule CETP inhibitors are summarized.

TL;DR: Findings suggest that cones may not have the same lipid requirements as rods, because PUFAs are necessary for optimal G protein-coupled receptor signaling in rods.

TL;DR: This work will examine the validity of the triglyceride hypothesis by detailing the biological complexities associated with hypertriglyceridemia, the genetic epidemiological evidence in favor of hypertrigovernmental triglycerides, the evidence from the fibrate randomized clinical trials relating triglycerides and clinical outcomes, and the completeness of theevidence from the initial studies of novel mutations.

TL;DR: Key mechanisms by which dietary OXLAMs contribute to NASH development are identified, including mitochondrial dysfunction, hepatocyte cell death, and NLRP3 inflammasome activation.