Deanna Toema

TL;DR: A quantitative molecular diagnostic approach improved population-level and case-level characterisation of the causes of diarrhoea and indicated a high burden of disease associated with six pathogens, for which targeted treatment should be prioritised.

TL;DR: It is recommended that future field trials of this clyA-based real-time polymerase chain reaction (qPCR) method and other novel diagnostics that detect typhoidal and nontyphoidal Salmonella employ multiple methodologies to define a "positive" sample.

TL;DR: Evaluated various blood treatment methods that could be used prior to PCR, real‐time PCR or MAMEF to increase sensitivity of detection of Salmonella.

TL;DR: It is found that significant protection could be achieved with two COPS:FliC doses, despite elicitation of modest serum anti-COPS IgG antibody titers, which guide potential immunization strategies that may be translated to develop a human pediatric iNTS vaccine for sub-Saharan Africa.

TL;DR: A composite severity score consistent with severe disease or dysentery may be a pragmatic clinical endpoint for severe shigellosis in vaccine trials.