Debbie Willoughby

TL;DR: The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.

TL;DR: Real-time cellular imaging experiments show that PKA anchoring with the cAMP synthesis machinery ensures rapid termination of cAMP signaling upon activation of the kinase, permitting the formation of a negative feedback loop that temporally regulates cAMP production.

TL;DR: It is proposed that gravin‐associated PDE4D isoforms provide a means to rapidly terminate subplasmalemmal cAMP signals with concomitant effects on localized ion channels or enzyme activities.

TL;DR: The demonstration that Orai1 functions as an integral component of a highly organized signaling complex to coordinate Ca2+ and cAMP signals underscores how SOC channels can be recruited to maximize the efficiency of the interplay between these two ubiquitous signaling pathways.

TL;DR: A review of cAMP biosensors for measuring cAMP at the single-cell level can be found in this article, where the authors compare their various operating principles and discuss their applications.