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Deborah A. Shear
Researcher at Walter Reed Army Institute of Research
Publications - 98
Citations - 3056
Deborah A. Shear is an academic researcher from Walter Reed Army Institute of Research. The author has contributed to research in topics: Traumatic brain injury & Morris water navigation task. The author has an hindex of 28, co-authored 90 publications receiving 2643 citations. Previous affiliations of Deborah A. Shear include Central Michigan University & Emory University.
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Biocompatibility of methylcellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury.
TL;DR: The use of methylcellulose as a scaffolding material, whose concentration and solvent were varied to manipulate its physical properties, indicates that MC is well suited as a biocompatible injectable scaffold for the repair of defects in the brain.
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Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain.
Ciara C. Tate,Deborah A. Shear,Matthew C. Tate,David R. Archer,Donald G. Stein,Michelle C. LaPlaca +5 more
TL;DR: Behaviour analyses indicated that mice receiving neural stem cells within the laminin‐based scaffold performed significantly better than untreated mice on a spatial learning task, supporting the notion that functional recovery correlates positively with donor cell survival.
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Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury.
TL;DR: Results show that 5 days of postinjury progesterone treatment are needed to reduce significantly the neuropathological and behavioral abnormalities found in a rodent model of TBI.
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Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury.
Deborah A. Shear,Matthew C. Tate,David R. Archer,Stuart W. Hoffman,Verne D. Hulce,Michelle C. LaPlaca,Donald G. Stein +6 more
TL;DR: Assessment of the long-term survival, migration, differentiation and functional significance of NPCs transplanted into a mouse model of TBI out to 1 year post-transplant concluded that transplanted NPCs survive in the host brain up to 14 months, migrate to the site of injury, enhance motor and cognitive recovery, and may play a role in trophic support following TBI.
Journal ArticleDOI
Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain.
Matthew C. Tate,Deborah A. Shear,Stuart W. Hoffman,Donald G. Stein,David R. Archer,Michelle C. LaPlaca +5 more
TL;DR: It is suggested that FGF2-responsive NSCs present a promising approach for cellular therapy following trauma and that the transplant location and environment may play an important role in graft survival and integration.