M
Michelle C. LaPlaca
Researcher at Georgia Institute of Technology
Publications - 95
Citations - 5161
Michelle C. LaPlaca is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Traumatic brain injury & Neural stem cell. The author has an hindex of 43, co-authored 92 publications receiving 4727 citations. Previous affiliations of Michelle C. LaPlaca include Walter Reed Army Institute of Research & University of Pennsylvania.
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Journal ArticleDOI
Biocompatibility of methylcellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury.
TL;DR: The use of methylcellulose as a scaffolding material, whose concentration and solvent were varied to manipulate its physical properties, indicates that MC is well suited as a biocompatible injectable scaffold for the repair of defects in the brain.
Journal ArticleDOI
High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model.
TL;DR: It is suggested that differential responses exist within a 3-D culture subjected to mechanical insult, perhaps mimicking the in vivo environment, and that this new model can be used to investigate the complex cellular mechanisms associated with TBI.
Journal ArticleDOI
Mechanical stretch to neurons results in a strain rate and magnitude-dependent increase in plasma membrane permeability.
TL;DR: Using an in vitro model of neuronal stretch, it is found that mechanical stretch of neurons resulted in a transient plasma membrane permeability increase, which may be the initiating mechanism that translates mechanical stretch to cellular dysfunction.
Journal ArticleDOI
Thermoreversible laminin-functionalized hydrogel for neural tissue engineering.
TL;DR: This bioadhesive thermoresponsive scaffold may provide a robust delivery vehicle to injured CNS tissue for neural cell transplantation strategies and is developed by tethering laminin-1 (LN) to methylcellulose (MC), a thermore sponsorsive hydrogel.
Book ChapterDOI
CNS injury biomechanics and experimental models.
TL;DR: Basic concepts relevant to the biomechanics of CNS trauma, injury models used to experimentally simulate TBI and SCI, and novel multilevel approaches for improving the current understanding of primary damage mechanisms are discussed.