Journal ArticleDOI
Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury.
Deborah A. Shear,Matthew C. Tate,David R. Archer,Stuart W. Hoffman,Verne D. Hulce,Michelle C. LaPlaca,Donald G. Stein +6 more
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TLDR
Assessment of the long-term survival, migration, differentiation and functional significance of NPCs transplanted into a mouse model of TBI out to 1 year post-transplant concluded that transplanted NPCs survive in the host brain up to 14 months, migrate to the site of injury, enhance motor and cognitive recovery, and may play a role in trophic support following TBI.About:
This article is published in Brain Research.The article was published on 2004-11-05. It has received 174 citations till now. The article focuses on the topics: Progenitor cell & Neural stem cell.read more
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Journal ArticleDOI
Animal models of traumatic brain injury
TL;DR: There is a compelling need to revisit the current status of animal models of TBI and therapeutic strategies, as promising neuroprotective drugs identified as being effective in animal TBI models have all failed in Phase II or Phase III clinical trials.
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The therapeutic potential of neural stem cells.
TL;DR: In this article, the authors discuss the alternative bystander mechanism in the context of the atypical ectopic perivascular niche and propose that it is the most challenging example of reciprocal therapeutic crosstalk between the inflamed CNS and systemically transplanted neural stem cells.
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Experimental models of traumatic brain injury: do we really need to build a better mousetrap?
Diego M. Morales,Niklas Marklund,David G. LeBold,Hilaire J. Thompson,Asla Pitkänen,William L. Maxwell,Luca Longhi,H. Laurer,M. Maegele,Edmund Neugebauer,David I. Graham,Nino Stocchetti,Tracy K. McIntosh +12 more
TL;DR: This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors.
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Gene therapy: can neural stem cells deliver?
TL;DR: It is speculated on the ways in which neural stem cells might be exploited as delivery vehicles for gene therapy in the CNS.
Journal ArticleDOI
β‐Catenin Signaling Promotes Proliferation of Progenitor Cells in the Adult Mouse Subventricular Zone
Kazuhide Adachi,Zaman Mirzadeh,Masanori Sakaguchi,Toru Yamashita,Toru Yamashita,Tania Nikolcheva,Yukiko Gotoh,Gary Peltz,Leyi Gong,Takeshi Kawase,Arturo Alvarez-Buylla,Hideyuki Okano,Kazunobu Sawamoto,Kazunobu Sawamoto +13 more
TL;DR: It is suggested that β‐catenin signaling plays a role in the proliferation of progenitor cells in the SVZ of the adult mouse brain.
References
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Journal ArticleDOI
Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Stem cells in the central nervous system.
TL;DR: The development of therapies for the reconstruction of the diseased or injured brain will be guided by the understanding of the origin and stability of cell type in the central nervous system.
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Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
Lars Björklund,Rosario Sanchez-Pernaute,Sangmi Chung,Therese Andersson,Therese Andersson,Iris Y. Chen,Kevin St. P. McNaught,Anna-Liisa Brownell,Bruce G. Jenkins,Claes Wahlestedt,Kwang-Soo Kim,Ole Isacson +11 more
TL;DR: It is shown that transplanting low doses of undifferentiated mouse embryonic stem cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons that can restore cerebral function and behavior in an animal model of Parkinson's disease.
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Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.
Karen S. Aboody,Alice B. Brown,Nikolai G. Rainov,Kate A. Bower,Shaoxiong Liu,Wendy Yang,Juan E. Small,Ulrich Herrlinger,Vaclav Ourednik,Peter McL. Black,Xandra O. Breakefield,Evan Y. Snyder +11 more
TL;DR: It is suggested that NSC migration can be extensive, even in the adult brain and along nonstereotypical routes, if pathology is present, and the adjunctive use of inherently migratory NSCs as a delivery vehicle for targeting therapeutic genes and vectors to refractory, migratory, invasive brain tumors is suggested.
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Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
Stefano Pluchino,Angelo Quattrini,Elena Brambilla,Angela Gritti,Giuliana Salani,Giorgia Dina,Rossella Galli,Ubaldo Del Carro,Stefano Amadio,Alessandra Bergami,Roberto Furlan,Giancarlo Comi,Angelo L. Vescovi,Gianvito Martino +13 more
TL;DR: In this article, adult neural stem cells were transplanted into mice to promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis.