D
Deborah E. Leckband
Researcher at University of Illinois at Urbana–Champaign
Publications - 195
Citations - 13017
Deborah E. Leckband is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Cadherin & Adhesion. The author has an hindex of 60, co-authored 189 publications receiving 12195 citations. Previous affiliations of Deborah E. Leckband include State University of New York System & University at Buffalo.
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Intermolecular forces in biology.
TL;DR: This work focuses on the application of adhesion mechanics of biological adhesion between ‘soft-supported’ membranes and proteins and non-equilibrium and time-dependent interactions: sequential events that evolve in space and time.
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Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
Quint le Duc,Quanming Shi,Iris Blonk,Arnoud Sonnenberg,Ning Wang,Deborah E. Leckband,Johan de Rooij +6 more
TL;DR: Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.
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Measuring the forces that control protein interactions.
TL;DR: Recent results obtained by using the atomic force microscope, optical tweezers, the surface force apparatus, and micropipette aspiration to quantify short-range protein-ligand interactions and the long-range, nonspecific forces that together control protein behavior are described.
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PNIPAM chain collapse depends on the molecular weight and grafting density.
TL;DR: It is demonstrated that the thermally induced collapse of end-grafted poly(N-isopropylacrylamide) (PNIPAM) above the lower critical solution temperature (LCST) of 32 degrees C depends on the chain grafting density and molecular weight.
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Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
TL;DR: This review addresses the cellular and molecular mechanisms of cadherin-based tissue morphogenesis by focusing on four key mechanistic elements: the molecular basis for adhesion through caderin ectodomains, the regulation of Cadherin expression at the cell surface, cooperation between cadherins and the actin cytoskeleton, and regulation by cell signaling.