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Quanming Shi
Researcher at Stanford University
Publications - 40
Citations - 2706
Quanming Shi is an academic researcher from Stanford University. The author has contributed to research in topics: Cadherin & Chromatin. The author has an hindex of 15, co-authored 33 publications receiving 1616 citations. Previous affiliations of Quanming Shi include University of Illinois at Urbana–Champaign & University of California, Berkeley.
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Journal ArticleDOI
Human Breast Cancer Invasion and Aggression Correlates with ECM Stiffening and Immune Cell Infiltration
Irene Acerbi,Luke Cassereau,Ivory Dean,Quanming Shi,Alfred Au,Catherine C. Park,Yunn-Yi Chen,Jan Liphardt,E. S. Hwang,Valerie M. Weaver +9 more
TL;DR: Findings indicate that human breast cancer progression and aggression, collagen linearization and stromal stiffening are linked and implicate tissue inflammation and TGF beta.
Journal ArticleDOI
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
Quint le Duc,Quanming Shi,Iris Blonk,Arnoud Sonnenberg,Ning Wang,Deborah E. Leckband,Johan de Rooij +6 more
TL;DR: Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.
Journal ArticleDOI
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
James K. Nuñez,Jin Chen,Greg C. Pommier,J. Zachery Cogan,Joseph M. Replogle,Carmen Adriaens,Carmen Adriaens,Gokul N. Ramadoss,Quanming Shi,King L. Hung,Avi J. Samelson,Angela N. Pogson,Angela N. Pogson,James Y.S. Kim,Amanda Chung,Manuel D. Leonetti,Howard Y. Chang,Howard Y. Chang,Martin Kampmann,Bradley E. Bernstein,Bradley E. Bernstein,Volker Hovestadt,Volker Hovestadt,Volker Hovestadt,Luke A. Gilbert,Jonathan S. Weissman,Jonathan S. Weissman +26 more
TL;DR: CRISPRoff as discussed by the authors is a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications, which can be used for heritable gene silencing.
Journal ArticleDOI
Rapid disorganization of mechanically interacting systems of mammary acini
Quanming Shi,Rajarshi P. Ghosh,Hanna Engelke,Chris H. Rycroft,Chris H. Rycroft,Luke Cassereau,James A. Sethian,James A. Sethian,Valerie M. Weaver,Jan Liphardt +9 more
TL;DR: Pairs or groups of mammary acini can interact mechanically over long distances through the collagen matrix, and these directed mechanical interactions facilitate transition to an invasive phenotype.
Journal ArticleDOI
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.
Ryan A. Flynn,Julia A. Belk,Yanyan Qi,Yuki Yasumoto,Jin Wei,Mia Madel Alfajaro,Quanming Shi,Maxwell R. Mumbach,Aditi Limaye,Peter C DeWeirdt,Cameron O. Schmitz,Kevin R. Parker,Elizabeth Woo,Howard Y. Chang,Tamas L. Horvath,Jan E. Carette,Carolyn R. Bertozzi,Craig B. Wilen,Ansuman T. Satpathy +18 more
TL;DR: In this paper, the authors identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection and integrated these data with ChIRP-MS data from three other RNA viruses to define viral specificity of RNA-host protein interactions.