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Deborah K. Froh
Researcher at University of Virginia
Publications - 16
Citations - 420
Deborah K. Froh is an academic researcher from University of Virginia. The author has contributed to research in topics: Cystic fibrosis & Ivacaftor. The author has an hindex of 6, co-authored 10 publications receiving 329 citations.
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Journal ArticleDOI
Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis.
Miriam M. Treggiari,George Z. Retsch-Bogart,Nicole Mayer-Hamblett,Umer Khan,Michal Kulich,Richard A. Kronmal,Judy Williams,Peter Hiatt,Ronald L. Gibson,Terry Spencer,David M. Orenstein,Barbara A. Chatfield,Deborah K. Froh,Jane L. Burns,Margaret Rosenfeld,Bonnie W. Ramsey +15 more
TL;DR: No difference in the rate of exacerbation or prevalence of P aeruginosa positivity was detected between cycled and culture-based therapies, and adding ciprofloxacin produced no benefits.
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Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis
Talissa A. Altes,Mac Johnson,Meredith C. Fidler,Martyn Botfield,Nicholas J. Tustison,Carlos Leiva-Salinas,Eduard E. de Lange,Deborah K. Froh,John P. Mugler +8 more
TL;DR: 3He-MRI provides an individual quantification of disease burden that may be able to detect aspects of the disease missed by population-based spirometry metrics, as assessed by human reader and computer algorithm.
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Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma
W. Gerald Teague,Monica G. Lawrence,Debbie-Ann Shirley,Andrea S. Garrod,Stephen V. Early,Jackie B. Payne,Julia A. Wisniewski,Peter W. Heymann,James J. Daniero,John W. Steinke,Deborah K. Froh,Thomas J. Braciale,Michael Ellwood,Drew A. Harris,Larry Borish +14 more
TL;DR: In children with severe, therapy-resistant asthma, BAL granulocyte patterns and infectious species are associated with novel phenotypic features that can inform pathway-specific revisions in treatment.
Journal ArticleDOI
Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study.
Talissa A. Altes,Talissa A. Altes,Craig H. Meyer,Jaime F. Mata,Deborah K. Froh,Alix Paget-Brown,W. Gerald Teague,Sean B. Fain,Eduard E. de Lange,Kai Ruppert,Martyn Botfield,Mac Johnson,John P. Mugler +12 more
TL;DR: Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained; focal ventilation defects were found in patients with respiratory diseases.
Journal ArticleDOI
Hyperpolarized Helium-3 Diffusion-weighted Magnetic Resonance Imaging Detects Abnormalities of Lung Structure in Children With Bronchopulmonary Dysplasia.
Lucia Flors,John P. Mugler,Alix Paget-Brown,Deborah K. Froh,Eduard E. de Lange,James T. Patrie,Talissa A. Altes +6 more
TL;DR: Children with BPD had higher ADCs and the same lung volumes when compared with age-matched healthy subjects, suggesting that children with B PD have enlarged alveoli that are reduced in number.