D
Declan J. McKeever
Researcher at Royal Veterinary College
Publications - 61
Citations - 2743
Declan J. McKeever is an academic researcher from Royal Veterinary College. The author has contributed to research in topics: Theileria parva & Antigen. The author has an hindex of 27, co-authored 61 publications receiving 2429 citations. Previous affiliations of Declan J. McKeever include International Livestock Research Institute & University of Edinburgh.
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Journal ArticleDOI
Zoonosis emergence linked to agricultural intensification and environmental change
Bryony A. Jones,Delia Grace,Richard Kock,Silvia Alonso,Jonathan Rushton,Mohammed Yahya Said,Declan J. McKeever,Florence Mutua,J. Young,John J. McDermott,Dirk U. Pfeiffer +10 more
TL;DR: It is concluded that the rate of future zoonotic disease emergence or reemergence will be closely linked to the evolution of the agriculture–environment nexus, and available research inadequately addresses the complexity and interrelatedness of environmental, biological, economic, and social dimensions of zoonosis.
Journal ArticleDOI
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Arnab Pain,Hubert Renauld,Matthew Berriman,Lee Murphy,Corin Yeats,William Weir,Arnaud Kerhornou,Martin Aslett,Richard P. Bishop,Christiane Bouchier,Madeleine Cochet,Richard M.R. Coulson,Ann Cronin,Etienne P. de Villiers,Audrey Fraser,Nigel Fosker,Malcolm J. Gardner,Arlette Goble,Sam Griffiths-Jones,David Harris,Frank Katzer,Natasha Larke,Angela Lord,Pascal Mäser,Sue McKellar,P. Mooney,Fraser R. Morton,Vishvanath Nene,Susan O'Neil,Claire Price,Michael A. Quail,Ester Rabbinowitsch,Neil D. Rawlings,Simon Rutter,David L. Saunders,Kathy Seeger,Trushar Shah,R. Squares,S. Squares,Adrian Tivey,Alan R. Walker,John Woodward,Dirk A. E. Dobbelaere,Gordon Langsley,Marie Adele Rajandream,Declan J. McKeever,Brian Shiels,Andrew Tait,Bart Barrell,Neil Hall +49 more
TL;DR: The genome of T. annulata is sequenced and the analysis reveals unequally expanded gene families and species-specific genes, and divergent families of putative secreted polypeptides that may reduce immune recognition.
Journal ArticleDOI
Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding efferent lymph.
Declan J. McKeever,Evans L. N. Taracha,E. L. Innes,Niall D. MacHugh,Elias Awino,Bruno Goddeeris,W. I. Morrison +6 more
TL;DR: Findings provide direct evidence that CD8+ T cells can control T. parva infections in immune cattle and enable adoptive transfer of this activity between immune and naive monozygotic twin calves.
Journal ArticleDOI
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
Harry Noyes,Andy Brass,Isaiah Obara,Susan Anderson,Alan Archibald,Daniel G. Bradley,Paul R. Fisher,Abigail R Freeman,John P. Gibson,Michael M. Gicheru,Laurence Hall,Olivier Hanotte,Helen Hulme,Declan J. McKeever,Caitriona Murray,Sung Jung Oh,Catriona Tate,Ken C. Smith,Miika Tapio,J Wambugu,Diana J. Williams,Morris Agaba,Stephen J. Kemp +22 more
TL;DR: Genetic analyses showed that selective sweeps had occurred at TICAM1 and ARHGAP15 loci in African taurine cattle, making them strong candidates for the genes underlying the QTL.
Journal ArticleDOI
Characterization of the Fine Specificity of Bovine CD8 T-Cell Responses to Defined Antigens from the Protozoan Parasite Theileria parva
Simon P. Graham,Roger Pelle,Mat Yamage,Duncan Mwangi,Yoshikazu Honda,Ramadhan S. Mwakubambanya,Etienne P. de Villiers,Evelyne Abuya,Elias Awino,James Gachanja,Ferdinand Mbwika,Anthony M. Muthiani,Cecelia Muriuki,John K. Nyanjui,Fredrick O. Onono,Julius Osaso,Victor Riitho,Rosemary Saya,Shirley A. Ellis,Declan J. McKeever,Niall D. MacHugh,Sarah C. Gilbert,Jean-Christophe Audonnet,W. Ivan Morrison,Pierre van der Bruggen,Evans L. N. Taracha +25 more
TL;DR: Identifying the epitopes recognized in six T. parva-immune cattle of different major histocompatibility complex (MHC) genotypes demonstrated that the identified antigens are inherently dominant in animals with the corresponding MHC genotypes.