P
Pierre van der Bruggen
Researcher at Université catholique de Louvain
Publications - 187
Citations - 14248
Pierre van der Bruggen is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 57, co-authored 187 publications receiving 13331 citations. Previous affiliations of Pierre van der Bruggen include Katholieke Universiteit Leuven & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Tumor-antigens recognized by T-lymphocytes
Thierry Boon,Jean-Charles Cerottini,Benoît Van den Eynde,Pierre van der Bruggen,Aline Van Pel +4 more
TL;DR: The identification of human tumor rejection antigens opens new possibilities for systematic approaches to the specific immune therapy of cancer.
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Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.
TL;DR: The characteristics of tumour antigens that are recognized by spontaneous T cell responses in cancer patients and the paths that led to their identification are described.
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T cell defined tumor antigens
TL;DR: The priority is now to demonstrate that immunization against some of these antigens is clinically valuable for antitumor therapy, and the first results of clinical pilot studies are now emerging.
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Human t cell responses against melanoma
TL;DR: In patients who do respond to the vaccine, the antivaccine T cells probably succeed in reversing focally this immunosuppression and trigger a broad activation of other antitumor T cells, which proceed to destroy the tumor.
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Structure, Chromosomal Localization, and Expression of 12 Genes of the Mage Family
Etienne De Plaen,Etienne De Plaen,Catia Traversari,Catia Traversari,José J. Gaforio,José J. Gaforio,Jean-Pierre Szikora,Jean-Pierre Szikora,Charles De Smet,Charles De Smet,Francis Brasseur,Francis Brasseur,Pierre van der Bruggen,Pierre van der Bruggen,Bernard Lethe,Bernard Lethe,Christophe Lurquin,Christophe Lurquin,Patrick Chomez,Patrick Chomez,Olivier De Backer,Olivier De Backer,Thierry Boon,Thierry Boon,Karen C. Arden,Webster K. Cavenee,Robert Brasseur +26 more
TL;DR: Six genes of the MAGE family including MAGE-1 were found to be expressed at a high level in a number of tumors of various histological types and none was expressed in a large panel of healthy tissues, with the exception of testis and placenta.