W
Wen Yang
Researcher at Harvard University
Publications - 8
Citations - 447
Wen Yang is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 3 publications receiving 308 citations. Previous affiliations of Wen Yang include Shanghai Jiao Tong University.
Papers
More filters
Journal ArticleDOI
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Wen Yang,Koji Nagasawa,Koji Nagasawa,Christian Münch,Yingjie Xu,Kyle Satterstrom,Seung Min Jeong,Sebastian D. Hayes,Mark P. Jedrychowski,F. Sejal Vyas,Elma Zaganjor,Virginia Guarani,Alison E. Ringel,Steven P. Gygi,J. Wade Harper,Marcia C. Haigis +15 more
TL;DR: The SIRT3-5 interaction network provides a framework for discovering novel biological functions regulated by mitochondrial sirtuins and identifies candidate sirtuin substrates, and uncovers a fundamental role for sequestration by ATP synthase in mitochondrial homeostasis.
Journal ArticleDOI
Acetylation-Dependent Regulation of Skp2 Function
Hiroyuki Inuzuka,Daming Gao,Lydia W.S. Finley,Wen Yang,Lixin Wan,Hidefumi Fukushima,Y. Rebecca Chin,Bo Zhai,Shavali Shaik,Alan W. Lau,Zhiwei Wang,Steven P. Gygi,Keiko Nakayama,Julie Teruya-Feldstein,Alex Toker,Marcia C. Haigis,Pier Paolo Pandolfi,Wenyi Wei +17 more
TL;DR: This study reports that Skp2 is acetylated by p300 at K68 and K71, which is a process that can be antagonized by the SIRT3 deacetylase, and identifies an acetylation-dependent regulatory mechanism governingSkp2 oncogenic function and provides insight into how cytoplasmic Skp 2 controls cellular migration.
Journal ArticleDOI
Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis
Jingjing Zhang,Yun Li,Hua Liu,Jiahui Zhang,Jie Wang,Jia Xia,Yu Jia Zhang,Xiangyang Ju,Jinyan Ma,Masha Huang,Jiahui Wang,Liangzhe Wang,Qian Li,Rutao Cui,Wen Yang,Yingjie Xu,Weiwei Feng +16 more
TL;DR: In this article , a CRISPR/Cas9 knockout screen was used to identify critical drivers of anoikis resistance using SKOV3 cell line and found protein-L-isoaspartate (D-aspartates) O-methyltransferase (PCMT1) as a candidate.
Journal ArticleDOI
Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis
Jingjing Zhang,Yun Li,Hua Liu,Jiahui Zhang,Jie Wang,Jia Xia,Yu Jia Zhang,Xiangyang Ju,Jinyan Ma,Masha Huang,Jiahui Wang,Liangzhe Wang,Qian Li,Rutao Cui,Wen Yang,Yingjie Xu,Weiwei Feng +16 more
TL;DR: In this article , a CRISPR/Cas9 knockout screen was used to identify critical drivers of anoikis resistance using SKOV3 cell line and found protein-L-isoaspartate (D-aspartates) O-methyltransferase (PCMT1) as a candidate.
Journal ArticleDOI
Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
You Ming Zhong,Yuanzhu Gao,Dejian Zhou,Xiaomin Ma,Huan Chen,Yingjie Xu,Wen Yang,Xiangyang Ju +7 more
TL;DR: In this paper , the 2.92 Å resolution cryo-electron microscopy (EM) structure of the E1 component 2-oxoglutarate dehydrogenase (OGDH) was reported.