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Delia Mezzanzanica
Researcher at University of Milan
Publications - 115
Citations - 4743
Delia Mezzanzanica is an academic researcher from University of Milan. The author has contributed to research in topics: Monoclonal antibody & Antigen. The author has an hindex of 38, co-authored 109 publications receiving 4363 citations. Previous affiliations of Delia Mezzanzanica include National Institutes of Health.
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Journal ArticleDOI
Characterization of human ovarian carcinoma‐associated antigens defined by novel monoclonal antibodies with tumor‐restricted specificity
Silvia Miotti,Silvana Canevari,Sylvie Ménard,Delia Mezzanzanica,G. Porro,Serenella M. Pupa,Mario Regazzoni,Elda Tagliabue,Maria I. Colnaghi +8 more
TL;DR: Three new monoclonal antibodies (MAbs) were raised against human ovarian carcinoma, and the properties of these antibodies, their restricted ovarian tumor specificities and relative high affinity constants suggest that they could represent promising tools for in vivo applications.
Journal ArticleDOI
Alterations of Choline Phospholipid Metabolism in Ovarian Tumor Progression
Egidio Iorio,Delia Mezzanzanica,Paola Alberti,Francesca Spadaro,Carlo Ramoni,Sandra D'Ascenzo,Danilo Millimaggi,Antonio Pavan,Vincenza Dolo,Silvana Canevari,Franca Podo +10 more
TL;DR: Evidence of abnormal phosphatidylcholine metabolism might have implications in EOC biology and might provide an avenue to the development of noninvasive clinical tools for EOC diagnosis and treatment follow-up.
Journal ArticleDOI
Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells
Egidio Iorio,Alessandro Ricci,Marina Bagnoli,Maria Elena Pisanu,Giancarlo Castellano,Massimo Di Vito,Elisa Venturini,Kristine Glunde,Zaver M. Bhujwalla,Delia Mezzanzanica,Silvana Canevari,Franca Podo +11 more
TL;DR: Overall, it was shown that the elevated PCho pool detected in EOC cells primarily resulted from upregulation/activation of ChoK and PC-plc involved in PC biosynthesis and degradation, respectively.
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Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer.
TL;DR: The role of c-FLIP(L) as anti-apoptotic pro-survival factor in tumors and the potential utility of this molecule as a possible alternative therapeutic target are discussed.
Journal Article
The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients.
Chiara Casati,Piero Dalerba,Licia Rivoltini,Gianfrancesco Gallino,Paola Deho,Francesca Rini,Filiberto Belli,Delia Mezzanzanica,Aurora Costa,Salvatore Andreola,Ermanno Leo,Giorgio Parmiani,Chiara Castelli +12 more
TL;DR: It is shown that the inhibitor of apoptosis protein, survivin, is immunogenic in colorectal cancer patients, and it is found that survivin elicited CD8(+) T cell-mediated responses in peripheral blood or in tumor-associated lymphocytes from patients at different disease stage.