Z
Zaver M. Bhujwalla
Researcher at Johns Hopkins University School of Medicine
Publications - 272
Citations - 15768
Zaver M. Bhujwalla is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 58, co-authored 256 publications receiving 14358 citations. Previous affiliations of Zaver M. Bhujwalla include Howard University & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
Rajani Ravi,Bijoyesh Mookerjee,Zaver M. Bhujwalla,Carrie Hayes Sutter,Dmitri Artemov,Qinwen Zeng,Larry E. Dillehay,Ashima Madan,Gregg L. Semenza,Atul Bedi +9 more
TL;DR: It is demonstrated that homozygous deletion of the p53 tumor suppressor gene via homologous recombination in a human cancer cell line promotes the neovascularization and growth of tumor xenografts in nude mice.
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Choline metabolism in malignant transformation
TL;DR: Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression, and increased levels of these compounds provide a non-invasive biomarker of transformation, staging and response to therapy.
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MRI of the tumor microenvironment.
TL;DR: This review attempts to identify techniques and their application to tumor biology, with an emphasis on nuclear magnetic resonance (NMR) approaches, using electron MR, optical, and radionuclear imaging techniques.
Journal Article
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
TL;DR: It is demonstrated that progression of human mammary epithelial cells from normal to malignant phenotype is associated with altered membrane choline phospholipid metabolism, and a "glycerophosphocholine to phosphocholine switch" was apparent with immortalization.
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HIF-dependent antitumorigenic effect of antioxidants in vivo.
Ping Gao,Huafeng Zhang,Ramani Dinavahi,Feng Li,Yan Xiang,Venu Raman,Zaver M. Bhujwalla,Dean W. Felsher,Linzhao Cheng,Jonathan Pevsner,Linda A. Lee,Gregg L. Semenza,Chi V. Dang +12 more
TL;DR: It is reported that antioxidants inhibited three tumorigenic models in vivo and challenge the paradigm that antioxidants diminish tumorigenesis primarily through decreasing DNA damage and mutations and provide significant support for a key antitumorigenic effect of diminishing HIF levels.