Demian van Straten

TL;DR: An overview of the clinical trials conducted over the last 10 years is provided, illustrating how PDT is applied in the clinic today, and the factors that hamper the exploration of this effective therapy and what should be changed to render it a more effective and more widely available option for patients.

TL;DR: The major issues for GBM treatment, the rationales of drug combinations with or without nanocarriers and the principle of enhanced permeability and retention effect involved in nanomedicine-based tumor targeting and promising nanodiagnostics or -therapeutics are discussed.

TL;DR: The hypothesis that tumor seeding can occur during colonoscopy via the working channel of the endoscope is supported, and primary tumor cells might be seeded in a new location after biopsy of the primary tumor.

TL;DR: This work indicates that CFZ-PM are potential drug carriers of carfilzomib, underlining the importance of the bone marrow crosstalk in testing novel formulations.

TL;DR: An overview of the clinical trials conducted over the last 10 years, illustrating how photodynamic therapy is applied in the clinic today, and examples from ongoing clinical trials and the most recent preclinical studies are presented, to show the directions in which PDT is headed, in the near and distant future as mentioned in this paper.