Marcel H.A.M. Fens

TL;DR: Post-insertion is proposed as a novel technique to confer targeting capacity to isolated EVs, circumventing the requirement to modify EV-secreting cells, and equips EVs with improved cell specificity and prolonged circulation times, potentially increasing EV accumulation in targeted tissues and improving cargo delivery.

TL;DR: By applying beneficial features of EVs to liposomes and vice versa, improved drug carriers can be developed which will advance the field of nanomedicines and ultimately improve patient outcomes.

TL;DR: Coupling of RGD to LCL redirected these liposomes to angiogenic endothelial cells in vitro and in vivo, and showed superior efficacy over non-targeted LCL in inhibiting C26 doxorubicin-insensitive tumor outgrowth.

TL;DR: In this paper, the preparation, release and in vitro cytotoxicity of a novel polymeric micellar formulation of paclitaxel (PTX) were investigated, where the loading was done by simply mixing of a small volume of a concentrated PTX solution in ethanol and an aqueous polymer solution and subsequent heating of the resulting solution above the critical micelle temperature of the polymer.

TL;DR: PTX-loaded micelles are developed which are stable without chemical cross-linking and covalent drug attachment, and are characterized by excellent loading capacity and strong drug retention, attributed to π-π stacking interaction between PTX and the aromatic groups of the polymer chains in the micellar core.