Showing papers in "Journal of Investigative Dermatology in 2017"

TL;DR: To assess the patient-level and societal burden of atopic dermatitis, the literature related to quality of life, social, economic, academic, and occupational impacts was comprehensively reviewed.

TL;DR: The wound healing assay, also known as the "in vitro scratch assay" is explained as a simple, versatile, and cost-effective method to study collective cell migration and wound healing.

TL;DR: In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections.

TL;DR: Differential gene expression by SFRP2+, FMO1+, and COL11A1+ fibroblasts suggests roles in matrix deposition, inflammatory cell retention, and connective tissue cell differentiation, respectively.

TL;DR: These studies identify tapinarof as an AhR agonist and confirm that its efficacy is dependent on AhR.

TL;DR: It is confirmed that approximately 20% of MCCs are not driven by MCPyV and that such virus-negative M CCs, which can be quite reliably identified by immunohistochemistry using the CM2B4 antibody alone, represent a more aggressive subtype that warrants closer clinical follow-up.

TL;DR: Evidence is provided that the dynamic wound microbiome is indicative of clinical outcomes and may be a valuable guide for personalized management and treatment of chronic wounds.

TL;DR: By calculating the surface area of follicular and the interfollicular epithelial surface it is shown that skin provides a vast interface for interactions with the microbiome.

TL;DR: It is suggested that specific changes in early-life skin colonization may actively contribute to clinical AD onset in infancy.

TL;DR: This review discusses microbiome research standards and highlights important factors to consider, including clinical study design, skin sampling, sample processing, DNA sequencing, control inclusion, and data analysis.

TL;DR: It is shown that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared with psoriasis and control unaffected skin, and Expression of CXCR3 is observed on most CD8TRM in vitILigo, including the population of melanocyte-specific CD8 T cells.

TL;DR: Cancer registry data from the Saarland and Schleswig-Holstein federal states were used to analyze incidence and mortality trends in Germany and there is a continuous long-term increase of NMSC incidence with no tendency for leveling off.

TL;DR: Nonlesional models showed the strongest correlations, with further improvement upon integration of serum markers and the hyperplasia score, and SCORAD correlated with immune and epidermal measures in lesional and, even more strongly, in nonlesional AD.

TL;DR: It is proposed that resident skin microbes may prevent exaggerated inflammatory responses by exerting a down-regulatory function and thereby maintaining a stable state under physiologic conditions and that short-chain fatty acids may be used therapeutically to mitigate inflammatory skin reactions.

TL;DR: Somatic mutations in TEK, the gene encoding TIE2, were discovered in 15 of 17 individuals with blue rubber bleb nevus syndrome and in five of six individuals with sporadically occurring multifocal venous malformations.

TL;DR: A large and longitudinal observational study on the epidemiology of Stevens-Johnson syndrome and toxic epidermal necrolysis in a European and largely white study population observes statistically significant associations between SJS/TEN and pre-existing depression, lupus erythematosus, recent pneumonia, chronic kidney disease, and active cancer.

TL;DR: Analysis of skin-infiltrating T cells suggests that inhibition of pathogenic IL-17 via tumor necrosis factor blockade is associated with improvement in immune dysregulation in HS and may provide a rationale for targeting IL- 17 in the disease.

TL;DR: Data suggest that it is possible to discriminate between biologics to inform clinical practice and decision making and that trial performance may not equate to real-world performance, and so results need to be considered alongside real- world, long-term safety and effectiveness data.

TL;DR: It is found that the epidermis is a chemokine-high niche in both a mouse model and human vitiligo, and topical therapies that target IFN-γ signaling in keratinocytes could be safe and effective new treatments, and skin expression of these chemokines could be used to monitor disease activity and treatment responses.

TL;DR: Using a cut-off for tumor thickness of 6 mm or greater, the presence of desmoplastic growth and immunosuppression identifies patients at high risk for tumor-specific death.

TL;DR: IL-15 was shown to enhance cytotoxicity of cultured natural killer cells and blister cells from patients with TEN and highlight a usefulness of IL-15 in prognosis monitoring and therapeutic intervention of this devastating condition.

TL;DR: This work elucidated whether adipose-derived stem cells (ADSCs) and their derivatives might induce neovascularization and protect skin flaps during ischemia/reperfusion (I/R) injury and increased flap recovery in I/R injury of IL-6-knockout mice.

TL;DR: Phenformin selectively inhibits granulocytic myeloid-derived suppressor cell-driven immune suppression and support that phenformin improves the anti-tumor activity of PD-1 blockade immunotherapy in melanoma is supported.

TL;DR: How S. aureus directly influences the skin barrier integrity by stimulating endogenous proteolytic activity is illustrated and defines a previously unknown mechanism by which S. aureus may influence skin diseases.

TL;DR: Three approaches consistently show that CsA reduces the mortality in epidermal necrolysis patients, including an instrumental variable-based approach, a case series approach, and a meta-analyzed approach.

TL;DR: Although it is clear that the ideal clinical application of transgenic epidermis would aim at preventing the development of devastating chronic lesions,manypatients suffer from therapyresistant chronic ulcerations that are highly predisposed to cancer development and need timely closure (Goldberg).

TL;DR: This study shows sustained benefit for lesions that respond early to topical imiquimod for superficial or nodular basal cell carcinoma at low-risk sites in the noninferiority randomized controlled SINS trial.

TL;DR: 5% imiquimod cream is superior to both methyl aminolevulinate photodynamic therapy and 5-fluorouracil cream in terms of efficacy for superficial basal cell carcinoma 5 years after treatment and is considered as the first choice for noninvasive treatment in most primary superficial basalcell carcinomas.

TL;DR: It is suggested that inflammatory cytokines promoted Nrf2 nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16, and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis.

TL;DR: Data from the BIOBADADERM registry was used to generate crude rates of infection during therapy with systemic drugs, including biological drugs (infliximab, etanercept, adalimumab, and ustekinumab) and nonbiological drugs (acitretin, cyclosporine, and methotrexate).