D
Denis Thieffry
Researcher at École Normale Supérieure
Publications - 181
Citations - 11701
Denis Thieffry is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Gene & Logical data model. The author has an hindex of 57, co-authored 180 publications receiving 10467 citations. Previous affiliations of Denis Thieffry include Max Planck Society & Aix-Marseille University.
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Dynamical analysis of a generic Boolean model for the control of the mammalian cell cycle
TL;DR: This work compares the respective advantages and limits of synchronous versus asynchronous updating assumptions to delineate the asymptotical behaviour of regulatory networks and proposes several intermediate strategies to optimize the computation of asymPTotical properties depending on available knowledge.
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Modularity in development and evolution.
Gerhard Schlosser,Denis Thieffry +1 more
TL;DR: This work offers a sustained exploration of modules from developmental and evolutionary perspectives, and discusses what modularity is, how it can be identified and modeled,How it originated and evolved, and why it matters.
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From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli
TL;DR: This paper presents a global characterization of the transcriptional regulation in Escherichia coli on the basis of the current data, with special emphasis given to circular sequences of interactions ("circuits") because of their critical dynamical properties.
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Dynamical behaviour of biological regulatory networks--I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state.
TL;DR: The recent concept of the loop-characteristic state, defined as the logical state located at the level of the thresholds involved in the loop, together with its application, are presented and their applications are discussed.
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GOToolBox: functional analysis of gene datasets based on Gene Ontology
TL;DR: Methods and tools allowing the identification of statistically over- or under-represented terms in a gene dataset; the clustering of functionally related genes within a set; and the retrieval of genes sharing annotations with a query gene are developed.