D
Dennis Kremer
Researcher at Leiden University Medical Center
Publications - 23
Citations - 3803
Dennis Kremer is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Single-nucleotide polymorphism & DNA methylation. The author has an hindex of 19, co-authored 23 publications receiving 3548 citations. Previous affiliations of Dennis Kremer include Leiden University.
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Journal ArticleDOI
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
Elmar W. Tobi,L. H. Lumey,L. H. Lumey,Rudolf P. Talens,Dennis Kremer,Hein Putter,Aryeh D. Stein,P. Eline Slagboom,Bastiaan T. Heijmans +8 more
TL;DR: Investigation of methylation of 15 loci implicated in growth and metabolic disease in individuals who were prenatally exposed to a war-time famine in 1944-45 indicates that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure.
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Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child.
Régine P.M. Steegers-Theunissen,Sylvia A. Obermann-Borst,Dennis Kremer,Jan Lindemans,Cissy Siebel,Eric A.P. Steegers,P. Eline Slagboom,Bastiaan T. Heijmans +7 more
TL;DR: Results indicate plasticity of IGF2 methylation by periconceptional folic acid use is associated with epigenetic changes in IGF2 in the child that may affect intrauterine programming of growth and development with consequences for health and disease throughout life.
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Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
Rudolf P. Talens,Dorret I. Boomsma,Elmar W. Tobi,Dennis Kremer,J. Wouter Jukema,Gonneke Willemsen,Hein Putter,P. Eline Slagboom,Bastiaan T. Heijmans +8 more
TL;DR: In this article, the authors characterized features of DNA methylation at 16 candidate loci, 8 of which were imprinted, in DNA samples from the Netherlands Twin Register biobank.
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Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs
Rudolf P. Talens,Kaare Christensen,Kaare Christensen,Hein Putter,Gonneke Willemsen,Lene Christiansen,Lene Christiansen,Dennis Kremer,H. Eka D. Suchiman,P. Eline Slagboom,Dorret I. Boomsma,Bastiaan T. Heijmans +11 more
TL;DR: S sustained epigenetic differences arise from early adulthood to old age and contribute to an increasing discordance of MZ twins during aging, as observed cross‐sectionally.
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Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
TL;DR: Variation in DNA methylation of the IGF2/H19 locus is mainly determined by heritable factors and single nucleotide polymorphisms (SNPs) in cis, rather than the cumulative effect of environmental and stochastic factors occurring with age.