D
Derrick T. Lin
Researcher at Massachusetts Eye and Ear Infirmary
Publications - 147
Citations - 5274
Derrick T. Lin is an academic researcher from Massachusetts Eye and Ear Infirmary. The author has contributed to research in topics: Free flap & Cancer. The author has an hindex of 30, co-authored 133 publications receiving 4112 citations. Previous affiliations of Derrick T. Lin include Harvard University & Vanderbilt University Medical Center.
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Journal ArticleDOI
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
Sidharth V. Puram,Itay Tirosh,Itay Tirosh,Anuraag S. Parikh,Anoop P. Patel,Keren Yizhak,Shawn M. Gillespie,Shawn M. Gillespie,Christopher Rodman,Christina L. Luo,Edmund A. Mroz,Kevin S. Emerick,Daniel G. Deschler,Daniel G. Deschler,Mark A. Varvares,Mark A. Varvares,Ravi Mylvaganam,Orit Rozenblatt-Rosen,James W. Rocco,James W. Rocco,James W. Rocco,William C. Faquin,Derrick T. Lin,Derrick T. Lin,Aviv Regev,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein +28 more
TL;DR: In this article, the authors profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell carcinoma (HNSCC) patients, including five matched pairs of primary tumors and lymph node metastases.
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Diagnostic and Prognostic Value of [18F]Fluorodeoxyglucose Positron Emission Tomography for Recurrent Head and Neck Squamous Cell Carcinoma
Richard J. Wong,Derrick T. Lin,Heiko Schöder,Snehal G. Patel,Mithat Gonen,Suzanne L. Wolden,David G. Pfister,Jatin P. Shah,Steven M. Larson,Dennis H. Kraus +9 more
TL;DR: PET was highly sensitive and specific at regional and distant sites, but at local sites, sensitivity was high, but specificity was lower because of false-positive findings.
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Withdrawal: Peroxisome proliferator-activated receptor γ ligands suppress the transcriptional activation of cyclooxygenase-2: Evidence for involvement of activator protein-1 and CREB-binding protein/p300.
TL;DR: This investigation investigated whether peroxisome proliferator-activated receptor gamma ligands inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells and raised questions about the mechanism underlying the anti-AP-1 effect of PPARgamma ligands.
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Cyclooxygenase‐2: A novel molecular target for the prevention and treatment of head and neck cancer
TL;DR: Evidence is presented that inhibition of COX‐2 represents a promising strategy to prevent or possibly treat human head and neck cancers.
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Proton Beam Radiation Therapy for Skull Base Adenoid Cystic Carcinoma
P. Pommier,N.J. Liebsch,Daniel G. Deschler,Derrick T. Lin,J.F. McIntyre,Fred G. Barker,Judy Adams,V.V. Lopes,Mark A. Varvares,Jay S. Loeffler,Annie W. Chan +10 more
TL;DR: High-dose conformal proton beam radiation therapy results in a very encouraging local control rate in patients with adenoid cystic carcinoma of the skull base and changes in vision at presentation and tumor involvement of the sphenoid sinus and clivus are important prognostic factors.